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C57BL/6JCya-Luc7l2em1/Cya
Common Name:
Luc7l2-KO
Product ID:
S-KO-03874
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Luc7l2-KO
Strain ID
KOCMP-192196-Luc7l2-B6J-VB
Gene Name
Luc7l2
Product ID
S-KO-03874
Gene Alias
4930471C18Rik; CGI59; Cgi74
Background
C57BL/6JCya
NCBI ID
192196
Modification
Conventional knockout
Chromosome
6
Phenotype
MGI:2183260
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Luc7l2em1/Cya mice (Catalog S-KO-03874) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000161538
NCBI RefSeq
NM_001170849
Target Region
Exon 5~7
Size of Effective Region
~3.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Luc7l2 is a gene encoding a protein that may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit [3]. It plays important roles in multiple biological processes, such as energy metabolism regulation, innate immune response, and DNA damage repair. It is also associated with various diseases including glioblastoma, liver cancer, chordoma, nasopharyngeal carcinoma, and myeloid neoplasms [1,3,4,6,8-10].

In glioblastoma, histone H3K9 lactylation activates LUC7L2 transcription. LUC7L2 then mediates intron 7 retention of MLH1, reducing MLH1 expression and inhibiting mismatch repair, leading to temozolomide resistance [1]. In liver cancer cells, LUC7L2 promotes proliferation and enhances DNA damage repair via RRAS [3]. In nasopharyngeal carcinoma, overexpression of LUC7L2 promotes radioresistance via autophagy, while knockdown sensitizes radio-resistant cells [5]. LUC7L2-deficient mice exhibit resistance to lethal herpes simplex virus 1 infection, as LUC7L2 negatively regulates the innate antiviral response by mediating MITA/STING intron retention [4]. Loss of LUC7L2 in cells shifts energy metabolism from glycolysis to oxidative phosphorylation (OXPHOS) through multiple splicing-related mechanisms [2].

In summary, Luc7l2 is a key gene involved in splicing regulation, which impacts diverse biological processes and disease-related pathways. The use of gene knockout or conditional knockout models, like the LUC7L2-deficient mice, has been crucial in revealing its role in diseases such as glioblastoma, liver cancer, nasopharyngeal carcinoma, and in antiviral immune response, providing insights into potential therapeutic strategies for these conditions.

References:

1. Yue, Qu, Wang, Zhao, Shen, Yixiong, Liu, Boyang, Guo, Hongbo. 2024. Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2309290. doi:10.1002/advs.202309290. https://pubmed.ncbi.nlm.nih.gov/38477507/

2. Jourdain, Alexis A, Begg, Bridget E, Mick, Eran, Burge, Christopher B, Mootha, Vamsi K. 2021. Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS. In Molecular cell, 81, 1905-1919.e12. doi:10.1016/j.molcel.2021.02.033. https://pubmed.ncbi.nlm.nih.gov/33852893/

3. Liu, Xinlei, Xie, Sijie, Jiang, Xiaoxue, Li, Shujie, Lu, Dongdong. 2024. LUC7L2 accelerates the growth of liver cancer cells by enhancing DNA damage repair via RRAS. In Cells & development, 180, 203976. doi:10.1016/j.cdev.2024.203976. https://pubmed.ncbi.nlm.nih.gov/39571735/

4. Li, Chen, Feng, Lu, Luo, Wei-Wei, Li, Mi, Shu, Hong-Bing. 2021. The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response. In Cell discovery, 7, 46. doi:10.1038/s41421-021-00277-y. https://pubmed.ncbi.nlm.nih.gov/34155193/

5. Shen, Lin, Li, Chao, Chen, Fang, Li, Zhanzhan, Li, Na. 2021. Nuclease technology genome-wide screening identifies LUC7L2 that promotes radioresistance via autophagy in nasopharyngeal carcinoma cells. In Cell death discovery, 7, 392. doi:10.1038/s41420-021-00783-8. https://pubmed.ncbi.nlm.nih.gov/34907164/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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