Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Osgin2em1/Cya
Common Name:
Osgin2-KO
Product ID:
S-KO-04644
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Osgin2-KO
Strain ID
KOCMP-209212-Osgin2-B6J-VA
Gene Name
Osgin2
Product ID
S-KO-04644
Gene Alias
C230027H09Rik
Background
C57BL/6JCya
NCBI ID
209212
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:2384798
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Osgin2em1/Cya mice (Catalog S-KO-04644) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000037198
NCBI RefSeq
NM_145950
Target Region
Exon 3
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Osgin2, an oxidative stress-induced factor, belongs to the Osgin gene family involved in the cellular oxidative stress response [7]. Although its biochemical role remains undefined, misregulation of Osgin2 has been associated with various diseases. It may play a part in pathways related to cell proliferation, apoptosis, and autophagy [7].

In osteoporotic rats, oxidative stress in jawbone bone marrow mesenchymal stem cells (BMSCs) is increased, along with up-regulation of Osgin2. Silence of Osgin2 ameliorates the declined osteogenesis of jawbone BMSCs under oxidative stress, restoring the expressions of RORα and its downstream osteogenic markers. Intra-jawbone infusion of si-OSGIN2 rescues jawbone loss and promotes new bone deposition [1]. In gastric cancer, high levels of Osgin2 in carcinoma cells and tissues are associated with a poor prognosis. Knockdown of Osgin2 inhibits tumor cell proliferation and causes cell cycle arrest [2]. In endothelial cells, the expression of Osgin2 is increased by cigarette smoke extract and TNFα under elevated flow, and knockdown of Osgin1&2 (including Osgin2) inhibits Nrf2-induced cell detachment [3]. In cadmium-exposed Tim-3 knockout mice, Osgin2 expression is affected, and Tim-3 deficiency aggravates cadmium nephrotoxicity [4]. In human dental-pulp-stem-cells-derived neurons, exposure to Ag-NPs changes the mRNA expression level of Osgin2 [5]. In soft-tissue sarcoma, miR-199a-5p regulates the 3'UTR of Osgin2 gene, and low miR-199a-5p expression is correlated with a poor patient outcome [6]. In colorectal cancer, Osgin2 is among the oxidative stress-related genes used to build a prognostic risk model [8]. In chicken breeds, Osgin2 is a candidate gene for cold adaptation [9]. In Ningqiang ponies, Osgin2 is associated with bone development [10].

In conclusion, Osgin2 is involved in multiple biological processes and disease conditions. Model-based research, such as gene knockdown experiments in different organisms, has revealed its role in osteogenesis, cancer cell proliferation, endothelial cell adhesion, cadmium-induced nephrotoxicity, and other biological functions related to oxidative stress, bone development, and environmental adaptation.

References:

1. Shuai, Yi, Liu, Bingyao, Rong, Liang, Chen, Bo, Jin, Lei. 2022. OSGIN2 regulates osteogenesis of jawbone BMSCs in osteoporotic rats. In BMC molecular and cell biology, 23, 22. doi:10.1186/s12860-022-00423-8. https://pubmed.ncbi.nlm.nih.gov/35729522/

2. Wang, Peipei, Zhu, Ying, Jia, Xinru, Sun, Leitao, Ruan, Shanming. 2023. Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro. In Scientific reports, 13, 5775. doi:10.1038/s41598-023-32934-5. https://pubmed.ncbi.nlm.nih.gov/37031243/

3. Satta, Sandro, Beal, Robert, Smith, Rhys, Newby, Andrew C, White, Stephen J. . A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion. In Cardiovascular research, 119, 1869-1882. doi:10.1093/cvr/cvad022. https://pubmed.ncbi.nlm.nih.gov/36804807/

4. Yin, Guanyi, Wang, Zhonghang, Li, Peiyao, Li, Xuemiao, Lou, Qiang. 2024. Tim-3 deficiency aggravates cadmium nephrotoxicity via regulation of NF-κB signaling and mitochondrial damage. In International immunopharmacology, 128, 111434. doi:10.1016/j.intimp.2023.111434. https://pubmed.ncbi.nlm.nih.gov/38176346/

5. Bonaventura, Gabriele, La Cognata, Valentina, Iemmolo, Rosario, D'Agata, Velia, Cavallaro, Sebastiano. 2018. Ag-NPs induce apoptosis, mitochondrial damages and MT3/OSGIN2 expression changes in an in vitro model of human dental-pulp-stem-cells-derived neurons. In Neurotoxicology, 67, 84-93. doi:10.1016/j.neuro.2018.04.014. https://pubmed.ncbi.nlm.nih.gov/29698629/

6. Keßler, Jacqueline, Rot, Swetlana, Bache, Matthias, Taubert, Helge, Greither, Thomas. 2016. miR-199a-5p regulates HIF-1α and OSGIN2 and its expression is correlated to soft-tissue sarcoma patients' outcome. In Oncology letters, 12, 5281-5288. doi:10.3892/ol.2016.5320. https://pubmed.ncbi.nlm.nih.gov/28101243/

7. Hussey, Grace, Royster, Marcus, Vaidy, Nivedha, Culkin, Michael, Saha, Margaret S. 2025. The Osgin Gene Family: Underexplored Yet Essential Mediators of Oxidative Stress. In Biomolecules, 15, . doi:10.3390/biom15030409. https://pubmed.ncbi.nlm.nih.gov/40149945/

8. Chen, Zilu, Mei, Kun, Xiao, Yao, Gu, Renjun, Wang, Bin. 2022. Prognostic Assessment of Oxidative Stress-Related Genes in Colorectal Cancer and New Insights into Tumor Immunity. In Oxidative medicine and cellular longevity, 2022, 2518340. doi:10.1155/2022/2518340. https://pubmed.ncbi.nlm.nih.gov/36299603/

9. Romanov, Michael N, Abdelmanova, Alexandra S, Fisinin, Vladimir I, Griffin, Darren K, Zinovieva, Natalia A. 2023. Selective footprints and genes relevant to cold adaptation and other phenotypic traits are unscrambled in the genomes of divergently selected chicken breeds. In Journal of animal science and biotechnology, 14, 35. doi:10.1186/s40104-022-00813-0. https://pubmed.ncbi.nlm.nih.gov/36829208/

10. Han, Jiale, Shao, Hanrui, Sun, Minhao, Li, Na, Dang, Ruihua. 2025. Genomic insights into the genetic diversity and genetic basis of body height in endangered Chinese Ningqiang ponies. In BMC genomics, 26, 292. doi:10.1186/s12864-025-11484-2. https://pubmed.ncbi.nlm.nih.gov/40128652/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest