Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Timp1em1/Cya
Common Name:
Timp1-KO
Product ID:
S-KO-05437
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Timp1-KO
Strain ID
KOCMP-21857-Timp1-B6J-VA
Gene Name
Timp1
Product ID
S-KO-05437
Gene Alias
Clgi; EPA; TIMP-1; TPA-S1; Timp
Background
C57BL/6JCya
NCBI ID
21857
Modification
Conventional knockout
Chromosome
X
Phenotype
MGI:98752
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Timp1em1/Cya mice (Catalog S-KO-05437) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000115342
NCBI RefSeq
NM_011593
Target Region
Exon 2~6
Size of Effective Region
~4.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Timp1, also known as tissue inhibitor of metalloproteinases-1, is named for its function of inhibiting the proteolytic activity of matrix metalloproteases. It can also modulate cell behavior through induction of signaling pathways involved in cell growth, proliferation, and survival [5].

In pancreatic cancer, TIMP1 significantly contributes to neutrophil extracellular trap (NET) formation in tumors. Abrogation of TIMP1 prolongs the survival of genetically engineered PDAC-bearing mice, indicating its role in promoting cancer progression [1]. In pancreatic ductal adenocarcinoma, TIMP1 forms a paracrine feedback loop with CCL7 between cancer cells and Schwann cells, promoting perineural invasion, and knockdown of TIMP1 can block this process [2]. In thyroid cancer, inhibiting TIMP1 expression reduces the malignant biological traits of papillary thyroid carcinoma cells and impedes M2 macrophage polarization while facilitating M1 macrophage polarization [3]. In subarachnoid haemorrhage, TIMP1 protects against blood-brain barrier disruption by inhibiting ubiquitination of astrocytic β1-integrin [4]. In type 2 diabetic osteoporosis, suppressing TIMP1 expression alleviates osteoporosis progression as TIMP1 promotes ferroptosis in osteoblasts [6]. In colorectal cancer, TIMP1 can be used as a biomarker associated with the immunological microenvironment, drug sensitivity, and ferroptosis inhibition [7].

In conclusion, Timp1 plays diverse roles in multiple biological processes and diseases. Model-based research, especially the use of gene knockout or conditional knockout mouse models in some cases, has revealed its significance in cancer progression, neural invasion in pancreatic cancer, immune regulation in thyroid cancer, blood-brain barrier protection, osteoporosis in diabetes, and biomarker potential in colorectal cancer. These findings help in understanding disease mechanisms and potentially developing new treatment strategies.

References:

1. Schoeps, Benjamin, Eckfeld, Celina, Prokopchuk, Olga, Hermann, Chris D, Krüger, Achim. 2021. TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer. In Cancer research, 81, 3568-3579. doi:10.1158/0008-5472.CAN-20-4125. https://pubmed.ncbi.nlm.nih.gov/33941611/

2. Tian, Zhenfeng, Ou, Guangsheng, Su, Mingxin, Huang, Kaihong, Chen, Yinting. 2022. TIMP1 derived from pancreatic cancer cells stimulates Schwann cells and promotes the occurrence of perineural invasion. In Cancer letters, 546, 215863. doi:10.1016/j.canlet.2022.215863. https://pubmed.ncbi.nlm.nih.gov/35961511/

3. Lin, Xu, Zhao, Ruhua, Bin, Yu, Xue, Gang, Wu, Jingfang. 2024. TIMP1 promotes thyroid cancer cell progression through macrophage phenotypic polarization via the PI3K/AKT signaling pathway. In Genomics, 116, 110914. doi:10.1016/j.ygeno.2024.110914. https://pubmed.ncbi.nlm.nih.gov/39128817/

4. Tang, Tianchi, Chen, Huaijun, Hu, Libin, Chen, Gao, Liu, Fuyi. 2024. TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic β1-integrin. In Stroke and vascular neurology, 9, 671-684. doi:10.1136/svn-2023-002956. https://pubmed.ncbi.nlm.nih.gov/38485231/

5. Justo, Beatriz Laís, Jasiulionis, Miriam Galvonas. 2021. Characteristics of TIMP1, CD63, and β1-Integrin and the Functional Impact of Their Interaction in Cancer. In International journal of molecular sciences, 22, . doi:10.3390/ijms22179319. https://pubmed.ncbi.nlm.nih.gov/34502227/

6. Peng, Bo, Feng, Zhiwei, Yang, Ao, Geng, Bin, Xia, Yayi. 2024. TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study. In Molecular medicine (Cambridge, Mass.), 30, 226. doi:10.1186/s10020-024-01000-9. https://pubmed.ncbi.nlm.nih.gov/39578773/

7. Qiu, Xiaode, Quan, Guangqian, Ou, Wenquan, Wang, Jian, Wu, Xiaohua. 2023. Unraveling TIMP1: a multifaceted biomarker in colorectal cancer. In Frontiers in genetics, 14, 1265137. doi:10.3389/fgene.2023.1265137. https://pubmed.ncbi.nlm.nih.gov/37842645/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest