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C57BL/6NCya-Rbm10em1/Cya
Common Name:
Rbm10-KO
Product ID:
S-KO-06853
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Rbm10-KO
Strain ID
KOCMP-236732-Rbm10-B6N-VA
Gene Name
Rbm10
Product ID
S-KO-06853
Gene Alias
E430039K10Rik; MINAS-60
Background
C57BL/6NCya
NCBI ID
236732
Modification
Conventional knockout
Chromosome
X
Phenotype
MGI:2384310
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Rbm10em1/Cya mice (Catalog S-KO-06853) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000115375
NCBI RefSeq
NM_001167775
Target Region
Exon 3~5
Size of Effective Region
~3.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rbm10, an RNA-binding protein, is a key regulator of alternative splicing of primary transcripts. It is involved in multiple cellular processes and is associated with pathways such as the p53-related tumor-suppression pathway. Mutations in Rbm10 can lead to TARP syndrome, an X-linked congenital pleiotropic developmental anomaly, and various cancers, highlighting its biological importance [1,2,3,4].

In an EGFR-driven lung adenocarcinoma (LUAD) mouse model, lung-specific ablation of Rbm10 promoted tumor development, similar to Trp53 ablation. Rbm10 loss led to overlapping gene expression changes enriched in cancer-related pathways and induced key RNA splicing changes in both mice and LUAD patients. Moreover, Rbm10 deficiency conferred high sensitivity to spliceosome inhibition in EGFR-mutated LUAD cells [5]. In thyroid cancer models, loss-of-function Rbm10 mutations, which are enriched in thyroid cancers with distant metastases, increased cell velocity and invasiveness through aberrant splicing of cytoskeletal and extracellular matrix mRNAs, leading to RAC1 activation [6].

In conclusion, Rbm10 plays a crucial role in regulating alternative splicing and is involved in tumor-related biological processes. The study of Rbm10 gene-knockout (KO) or conditional-knockout (CKO) mouse models has revealed its significance in lung and thyroid cancers, providing insights into disease mechanisms and potential therapeutic strategies.

References:

1. Inoue, Akira. 2021. RBM10: Structure, functions, and associated diseases. In Gene, 783, 145463. doi:10.1016/j.gene.2021.145463. https://pubmed.ncbi.nlm.nih.gov/33515724/

2. Jung, Ji Hoon, Lee, Hyemin, Zeng, Shelya X, Lu, Hua. 2020. RBM10, a New Regulator of p53. In Cells, 9, . doi:10.3390/cells9092107. https://pubmed.ncbi.nlm.nih.gov/32947864/

3. Cao, Yingshu, Di, Xin, Zhang, Qinghua, Li, Ranwei, Wang, Ke. 2021. RBM10 Regulates Tumor Apoptosis, Proliferation, and Metastasis. In Frontiers in oncology, 11, 603932. doi:10.3389/fonc.2021.603932. https://pubmed.ncbi.nlm.nih.gov/33718153/

4. Loiselle, Julie J, Sutherland, Leslie C. 2018. RBM10: Harmful or helpful-many factors to consider. In Journal of cellular biochemistry, 119, 3809-3818. doi:10.1002/jcb.26644. https://pubmed.ncbi.nlm.nih.gov/29274279/

5. Bao, Yufang, Zhang, Sirui, Zhang, Xiaoyu, Wang, Zefeng, Wang, Yongbo. . RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity to Spliceosome Inhibition. In Cancer research, 83, 1490-1502. doi:10.1158/0008-5472.CAN-22-1549. https://pubmed.ncbi.nlm.nih.gov/36853175/

6. Krishnamoorthy, Gnana P, Glover, Anthony R, Untch, Brian R, Bradley, Robert K, Fagin, James A. 2025. RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs. In The Journal of experimental medicine, 222, . doi:10.1084/jem.20241029. https://pubmed.ncbi.nlm.nih.gov/39992626/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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