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C57BL/6JCya-Mamstrem1/Cya
Common Name:
Mamstr-KO
Product ID:
S-KO-14445
Background:
C57BL/6JCya
Product Type
Age
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Sex
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Basic Information
Strain Name
Mamstr-KO
Strain ID
KOCMP-74490-Mamstr-B6J-VA
Gene Name
Mamstr
Product ID
S-KO-14445
Gene Alias
2810022D01Rik; 5430432N15Rik; Mastr
Background
C57BL/6JCya
NCBI ID
74490
Modification
Conventional knockout
Chromosome
7
Phenotype
MGI:1921740
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mamstrem1/Cya mice (Catalog S-KO-14445) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000148532
NCBI RefSeq
NM_172418
Target Region
Exon 3~7
Size of Effective Region
~2.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Mamstr, also known as Myocyte enhancer factor-2-activating motif and SAP domain-containing transcriptional regulator, is a transcriptional regulator. It binds to promoter regions to regulate downstream genes, and is involved in transcriptional regulation, metabolic pathways, and cell development and differentiation, such as in the AMPK, TGF-beta, and adipocytokine signaling pathways, as well as fat digestion and absorption, and skeletal muscle-related processes [1]. It is a member of the myocardin family, which binds to the transcription factor serum response factor (SRF) and acts as co-activators controlling genes relevant for myogenic differentiation and motile function [3].

In the dy2J/dy2J mouse model of Lama2-CMD (Congenital muscular dystrophy type-1A), the down-regulation of Mamstr was detected compared to wild-type mice. This finding may explain the progressive dystrophic process in this model, as opposed to the massive regeneration seen in the mdx mouse model where key regeneration genes were up-regulated. This indicates that Mamstr is involved in the impaired skeletal muscle regeneration in the dy2J/dy2J mouse model [2].

In summary, Mamstr is crucial for transcriptional regulation and cell development-related processes, especially in skeletal muscle. The study of the dy2J/dy2J mouse model has revealed its role in the pathophysiology of Lama2-CMD, suggesting that understanding Mamstr may provide insights into muscle-related disease mechanisms and potential therapeutic targets.

References:

1. Li, Chenlei, Zhang, Zhe, Wei, Yilin, Yang, Feng, Han, Xuelei. 2023. Genome-Wide Analysis of MAMSTR Transcription Factor-Binding Sites via ChIP-Seq in Porcine Skeletal Muscle Fibroblasts. In Animals : an open access journal from MDPI, 13, . doi:10.3390/ani13111731. https://pubmed.ncbi.nlm.nih.gov/37889674/

2. Yanay, Nurit, Elbaz, Moran, Konikov-Rozenman, Jenya, Mitrani-Rosenbaum, Stella, Nevo, Yoram. . Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD. In Human molecular genetics, 28, 3369-3390. doi:10.1093/hmg/ddz180. https://pubmed.ncbi.nlm.nih.gov/31348492/

3. Swärd, Karl, Stenkula, Karin G, Rippe, Catarina, Gomez, Maria F, Albinsson, Sebastian. 2016. Emerging roles of the myocardin family of proteins in lipid and glucose metabolism. In The Journal of physiology, 594, 4741-52. doi:10.1113/JP271913. https://pubmed.ncbi.nlm.nih.gov/27060572/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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