C57BL/6JCya-Atg16l2em1/Cya
Common Name
Atg16l2-KO
Product ID
S-KO-16161
Backgroud
C57BL/6JCya
Strain ID
KOCMP-73683-Atg16l2-B6J-VA
When using this mouse strain in a publication, please cite “Atg16l2-KO Mouse (Catalog S-KO-16161) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Atg16l2-KO
Strain ID
KOCMP-73683-Atg16l2-B6J-VA
Gene Name
Product ID
S-KO-16161
Gene Alias
2410118P20Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000120267
NCBI RefSeq
NM_001111111
Target Region
Exon 3
Size of Effective Region
~0.1 kb
Overview of Gene Research
ATG16L2, an autophagic protein and paralog of ATG16L1, is involved in autophagy, a crucial cell process for nutrient recycling and pathogen defense [1]. While ATG16L1 has been well-studied, ATG16L2 was relatively uncharacterized. It is implicated in various diseases such as cancer, inflammatory bowel diseases, and neurodegenerative disorders [1].
ATG16L2-deficient macrophages show attenuated LPS-induced autophagy flux through mediating ATG5-12-16L1 complex assembly, and elevated NLRP3 inflammasome activation, along with mitochondrial defects [2]. ATG16L2-knockout mice are more susceptible to DSS-induced intestinal damage, which can be improved by NLRP3 inhibition [2]. Also, ATG16L2-deficient macrophages exhibit reduced NLRC4 inflammasome activation, and ATG16L2-knockout mice infected with Salmonella typhimurium have decreased pathogen clearance and survival rates [3].
In conclusion, ATG16L2 positively regulates autophagy and plays a significant role in modulating inflammasome activation, including NLRP3 and NLRC4 inflammasomes. The ATG16L2 knockout mouse models have revealed its importance in intestinal damage response and host defense against intracellular pathogens, highlighting its potential as a target for treating inflammatory diseases [2,3].
References:
1. Don Wai Luu, Laurence, Kaakoush, Nadeem O, Castaño-Rodríguez, Natalia. 2022. The role of ATG16L2 in autophagy and disease. In Autophagy, 18, 2537-2546. doi:10.1080/15548627.2022.2042783. https://pubmed.ncbi.nlm.nih.gov/35239457/
2. Wang, Dongyang, Yuan, Tianli, Liu, Jiamin, Wang, Zheng, Wu, Xuefeng. 2022. ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy. In European journal of immunology, 52, 1321-1334. doi:10.1002/eji.202149764. https://pubmed.ncbi.nlm.nih.gov/35426127/
3. Wen, Zhoujin, Yuan, Tianli, Liu, Jiamin, Wu, Xuefeng, Wang, Zheng. 2024. Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association. In European journal of immunology, 54, e2451078. doi:10.1002/eji.202451078. https://pubmed.ncbi.nlm.nih.gov/39175123/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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