C57BL/6JCya-Loxl2em1/Cya
Common Name
Loxl2-KO
Product ID
S-KO-17930
Backgroud
C57BL/6JCya
Strain ID
KOCMP-94352-Loxl2-B6J-VB
When using this mouse strain in a publication, please cite “Loxl2-KO Mouse (Catalog S-KO-17930) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Loxl2-KO
Strain ID
KOCMP-94352-Loxl2-B6J-VB
Gene Name
Product ID
S-KO-17930
Gene Alias
1110004B06Rik, 4930526G11Rik, 9430067E15Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000100420
NCBI RefSeq
NM_033325
Target Region
Exon 13~14
Size of Effective Region
~1.4 kb
Overview of Gene Research
Loxl2, short for Lysyl Oxidase Like 2, belongs to the lysyl oxidase (LOX) family. It is a copper and lysine tyrosyl-quinone (LTQ)-dependent amine oxidase. Its canonical function is to catalyze the cross-linking of elastin and collagen in the extracellular matrix (ECM), playing a central role in fibrosis [1,2,3]. It is involved in multiple pathways related to tumor progression, such as epithelial-mesenchymal transition (EMT), metastasis, and chemoradiotherapy resistance [1,3]. Genetically modified mouse models have been crucial in exploring its in-vivo role [1].
In pancreatic ductal adenocarcinoma (PDAC) mouse models, Loxl2 ablation had little effect on primary tumor development but significantly decreased metastasis and increased overall survival, attributed to non-cell autonomous factors like ECM remodelling. Conversely, Loxl2 overexpression promoted primary and metastatic tumor growth and decreased overall survival, linked to increased EMT and stemness [4].
In conclusion, Loxl2 is essential for ECM cross-linking. Model-based research, especially PDAC mouse models, has shown that Loxl2 plays a significant role in cancer metastasis and overall survival, highlighting its potential as a therapeutic target in cancer treatment [4].
References：
1. Cano, Amparo, Eraso, Pilar, Mazón, María J, Portillo, Francisco. 2023. LOXL2 in Cancer: A Two-Decade Perspective. In International journal of molecular sciences, 24, . doi:10.3390/ijms241814405. https://pubmed.ncbi.nlm.nih.gov/37762708/
2. Cheng, Fang, Yang, Fuji, Wang, Yanjin, Qian, Hui, Yan, Yongmin. 2023. Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway. In Journal of nanobiotechnology, 21, 195. doi:10.1186/s12951-023-01942-y. https://pubmed.ncbi.nlm.nih.gov/37328872/
3. Wen, Bing, Xu, Li-Yan, Li, En-Min. 2020. LOXL2 in cancer: regulation, downstream effectors and novel roles. In Biochimica et biophysica acta. Reviews on cancer, 1874, 188435. doi:10.1016/j.bbcan.2020.188435. https://pubmed.ncbi.nlm.nih.gov/32976981/
4. Alonso-Nocelo, Marta, Ruiz-Cañas, Laura, Sancho, Patricia, Cano, Amparo, Sainz, Bruno. 2022. Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma. In Gut, 72, 345-359. doi:10.1136/gutjnl-2021-325564. https://pubmed.ncbi.nlm.nih.gov/35428659/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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