C57BL/6JCya-Slc31a2em1/Cya
Common Name:
Slc31a2-KO
Product ID:
S-KO-18144
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc31a2-KO
Strain ID
KOCMP-20530-Slc31a2-B6J-VB
Gene Name
Product ID
S-KO-18144
Gene Alias
CTR2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc31a2em1/Cya mice (Catalog S-KO-18144) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000084530
NCBI RefSeq
NM_025286
Target Region
Exon 2~4
Size of Effective Region
~5.8 kb
Detailed Document
Overview of Gene Research
Slc31a2, also known as CTR2, is a member of the SLC31 family of solute carriers involved in regulating intracellular copper (Cu²⁺) concentration. Along with SLC31A1, it is part of a protein network maintaining Cu²⁺ homeostasis [1]. SLC31A2 is mainly found in the intracellular membranes of the late endosome and lysosome, though its specific function remains unknown [1].
Studies have associated SLC31A2 with several diseases. In atherosclerosis, its expression was significantly higher in plaques compared to normal intimae, suggesting its potential as a diagnostic biomarker [2]. In hepatocellular carcinoma, the DNA-methylation level of a site in the promoter region of SLC31A2 was different between tumor and normal tissue, indicating a possible role in the disease's advancement [3]. In melanoma, SLC31A2 was associated with resistance to most chemotherapeutic agents [4]. In lung adenocarcinoma, a gene signature including SLC31A2 showed good clinical value in prognostic assessment [5]. It was also identified in gene signatures related to responses to platin chemotherapy agents [6].
In conclusion, while the specific function of SLC31A2 is yet to be fully elucidated, research indicates its potential importance in multiple disease areas such as atherosclerosis, hepatocellular carcinoma, melanoma, and lung adenocarcinoma. These disease-related associations, identified through various studies, contribute to our understanding of the role SLC31A2 may play in different biological processes related to these diseases.
References:
1. Schweigel-Röntgen, Monika. . The families of zinc (SLC30 and SLC39) and copper (SLC31) transporters. In Current topics in membranes, 73, 321-55. doi:10.1016/B978-0-12-800223-0.00009-8. https://pubmed.ncbi.nlm.nih.gov/24745988/
2. Chen, Yong-Tong, Xu, Xuan-Hao, Lin, Ling, Tian, Shuai, Wu, Gui-Fu. 2023. Identification of Three Cuproptosis-specific Expressed Genes as Diagnostic Biomarkers and Therapeutic Targets for Atherosclerosis. In International journal of medical sciences, 20, 836-848. doi:10.7150/ijms.83009. https://pubmed.ncbi.nlm.nih.gov/37324184/
3. Zhu, Rui, Wang, Xue, Sun, Fenyong, Zhu, Liucun, Guo, Wenna. . Exploring the Role of DNA Methylation Located in Cuproptosis-Related Genes: Implications for Prognosis and Immune Landscape in Hepatocellular Carcinoma. In Frontiers in bioscience (Landmark edition), 29, 123. doi:10.31083/j.fbl2903123. https://pubmed.ncbi.nlm.nih.gov/38538282/
4. Zhou, Bin, Sha, Shanshan, Tao, Juan, Dong, Liyun, Huang, Changzheng. 2022. The expression pattern of pyroptosis-related genes predicts the prognosis and drug response of melanoma. In Scientific reports, 12, 21566. doi:10.1038/s41598-022-24879-y. https://pubmed.ncbi.nlm.nih.gov/36513682/
5. Chang, Wuguang, Li, Hongmu, Zhong, Leqi, Ou, Wei, Wang, Siyu. 2022. Development of a copper metabolism-related gene signature in lung adenocarcinoma. In Frontiers in immunology, 13, 1040668. doi:10.3389/fimmu.2022.1040668. https://pubmed.ncbi.nlm.nih.gov/36524120/
6. Mucaki, Eliseos J, Zhao, Jonathan Z L, Lizotte, Daniel J, Rogan, Peter K. 2019. Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning. In Signal transduction and targeted therapy, 4, 1. doi:10.1038/s41392-018-0034-5. https://pubmed.ncbi.nlm.nih.gov/30652029/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen