C57BL/6JCya-Psmc2em1/Cya
Common Name:
Psmc2-KO
Product ID:
S-KO-18253
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Psmc2-KO
Strain ID
KOCMP-19181-Psmc2-B6J-VB
Gene Name
Product ID
S-KO-18253
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Psmc2em1/Cya mice (Catalog S-KO-18253) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000030769
NCBI RefSeq
NM_011188
Target Region
Exon 4
Size of Effective Region
~0.1 kb
Detailed Document
Overview of Gene Research
Psmc2, Proteasome 26S subunit, ATPase 2, is an essential part of the 19S regulatory complex of the 26S proteasome. It catalyzes the unfolding and transport of substrates into the 20S proteasome, playing a crucial role in proteasome-mediated protein degradation, which is involved in multiple cellular processes such as cell cycle regulation, apoptosis, and DNA damage repair [6]. Gene knockout or knockdown models are valuable for studying its functions.
Knockdown of Psmc2 has been shown to have significant impacts in various cancers. In oral squamous cell carcinoma (OSCC), Psmc2 knockdown inhibited cell proliferation, migration, and promoted apoptosis via the PI3K/Akt pathway, suppressing tumor growth [1]. In glioma, it inhibited cell proliferation and promoted apoptosis, and in skin cutaneous melanoma, it suppressed tumor progression by inhibiting cell proliferation, migration, DNA damage, and inducing apoptosis and cell cycle arrest [2,3]. Similar anti-tumor effects were observed in gastric cancer, nasopharyngeal carcinoma, hepatocellular carcinoma, ovarian cancer, and pancreatic cancer, with Psmc2 knockdown affecting cell growth, apoptosis, and migration through various pathways like RPS15A/mTOR, AKT, and by regulating related proteins [4,5,7,8,9].
In conclusion, Psmc2 plays a critical role in promoting the progression of multiple cancers by regulating cell growth, apoptosis, and migration. Studies using Psmc2 knockdown models have revealed its oncogenic functions in various disease areas, suggesting that targeting Psmc2 could be a potential therapeutic strategy for these cancers.
References:
1. Wang, Zijia, Xiong, Haofeng, Zuo, Yijie, Zhu, Chao, Min, Anjie. 2022. PSMC2 knockdown inhibits the progression of oral squamous cell carcinoma by promoting apoptosis via PI3K/Akt pathway. In Cell cycle (Georgetown, Tex.), 21, 477-488. doi:10.1080/15384101.2021.2021722. https://pubmed.ncbi.nlm.nih.gov/34979867/
2. Zheng, Xiaoyang, Wang, Yuguang, Wang, Dongxu, Mu, Zhuang, Hu, Nan. 2022. PSMC2 is overexpressed in glioma and promotes proliferation and anti-apoptosis of glioma cells. In World journal of surgical oncology, 20, 84. doi:10.1186/s12957-022-02533-1. https://pubmed.ncbi.nlm.nih.gov/35287689/
3. Yang, Yanwen, Qi, Fazhi, Wei, Chuanyuan, Luan, Wenjie, Gu, Jianying. 2021. PSMC2 knockdown suppressed tumor progression of skin cutaneous melanoma. In Cell death discovery, 7, 323. doi:10.1038/s41420-021-00727-2. https://pubmed.ncbi.nlm.nih.gov/34716318/
4. Liu, Tao, Zhang, Junling, Chen, Hu, Jiang, Yong, Yang, Zhen. 2022. PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway. In Oncogenesis, 11, 12. doi:10.1038/s41389-022-00386-7. https://pubmed.ncbi.nlm.nih.gov/35256584/
5. Su, Jin, Hu, Shousen, Ding, Shiping, Feng, Kun. 2024. PSMC2 knockdown exerts an anti-tumor role in nasopharyngeal carcinoma through regulating AKT signaling pathway. In Cell cycle (Georgetown, Tex.), 22, 2381-2391. doi:10.1080/15384101.2023.2293590. https://pubmed.ncbi.nlm.nih.gov/38123344/
6. Huang, Wei, Qian, Zhengtao, Shi, Yuxin, Xu, Junying, Ding, Junli. 2023. PSMC2 is a Novel Prognostic Biomarker and Predicts Immunotherapeutic Responses: From Pancreatic Cancer to Pan-Cancer. In Pharmacogenomics and personalized medicine, 16, 747-758. doi:10.2147/PGPM.S418533. https://pubmed.ncbi.nlm.nih.gov/37581119/
7. Duan, Xuhua, Li, Hao, Wang, Manzhou, Han, Xinwei, Ren, Jianzhuang. 2021. PSMC2/ITGA6 axis plays critical role in the development and progression of hepatocellular carcinoma. In Cell death discovery, 7, 217. doi:10.1038/s41420-021-00585-y. https://pubmed.ncbi.nlm.nih.gov/34413286/
8. Zhu, Dawei, Huang, Jie, Liu, Ning, Li, Wei, Yan, Limei. 2021. PSMC2/CCND1 axis promotes development of ovarian cancer through regulating cell growth, apoptosis and migration. In Cell death & disease, 12, 730. doi:10.1038/s41419-021-03981-5. https://pubmed.ncbi.nlm.nih.gov/34294689/
9. Qin, Jing, Wang, Wangsheng, An, Fangmei, Huang, Wei, Ding, Junli. 2019. PSMC2 is Up-regulated in Pancreatic Cancer and Promotes Cancer Cell Proliferation and Inhibits Apoptosis. In Journal of Cancer, 10, 4939-4946. doi:10.7150/jca.27616. https://pubmed.ncbi.nlm.nih.gov/31598166/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen