C57BL/6JCya-Gins1em1/Cya
Common Name
Gins1-KO
Product ID
S-KO-18399
Backgroud
C57BL/6JCya
Strain ID
KOCMP-69270-Gins1-B6J-VB
When using this mouse strain in a publication, please cite “Gins1-KO Mouse (Catalog S-KO-18399) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Gins1-KO
Strain ID
KOCMP-69270-Gins1-B6J-VB
Gene Name
Product ID
S-KO-18399
Gene Alias
2810418N01Rik, Gins4, PSF1, mKIAA0186
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000028948
NCBI RefSeq
NM_027014
Target Region
Exon 2
Size of Effective Region
~1.5 kb
Overview of Gene Research
GINS1, a subunit of the GINS complex, functions in eukaryotic DNA replication along with the MCM2-7 complex and Cdc45 [3]. It is involved in regulating DNA replication in the initiation and elongation phases, which is crucial for cell cycle modulation and thus has overall significance in cellular proliferation [2,4].
GINS1 has been found to be overexpressed in several cancers. In diffuse large B-cell lymphoma (DLBCL), FOXP1 transcriptionally activates GINS1 expression, and the FOXP1-GINS1 axis promotes DLBCL proliferation and doxorubicin resistance [1]. In hepatocellular carcinoma (HCC), GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and tumor metastasis via β-catenin signaling [2]. In glioma, GINS1 promotes cell proliferation and migration through USP15-mediated deubiquitination of TOP2A [3]. In bladder cancer, GINS1 promotes the initiation and progression by activating the AKT/mTOR/c-Myc signaling pathway [4]. High GINS1 expression is also associated with poor prognosis in gastric cancer, sarcoma, and HCC, and it can induce sorafenib resistance in HCC by promoting cancer stem properties [5,6,7]. In lung adenocarcinoma, GINS1 facilitates development via Wnt/β-catenin activation [8].
In conclusion, GINS1 plays a significant role in DNA replication and cell cycle-related processes. Its overexpression in various cancers, as revealed through in vivo and functional studies, suggests its potential as a prognostic biomarker and therapeutic target in multiple cancer types. The understanding of GINS1's functions in these disease conditions has been enhanced through research on its expression and regulatory mechanisms in different cancer models [1-10].
References：
1. Chen, Zhenfa, Wang, Ting, Li, Cui, Wang, Jundong, Li, Shufeng. 2023. FOXP1-GINS1 axis promotes DLBCL proliferation and directs doxorubicin resistance. In Journal of Cancer, 14, 2289-2300. doi:10.7150/jca.85906. https://pubmed.ncbi.nlm.nih.gov/37576391/
2. Liang, Junjie, Yao, Nan, Deng, Bo, Cao, Mingrong, Hong, Jian. 2024. GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and tumor metastasis via β-catenin signaling in hepatocellular carcinoma. In Journal of cellular physiology, 239, e31237. doi:10.1002/jcp.31237. https://pubmed.ncbi.nlm.nih.gov/38468464/
3. Yang, Hui, Liu, Xiaocen, Zhu, Xiaolong, Ma, Mingzhe, Lv, Kun. 2022. GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A. In iScience, 25, 104952. doi:10.1016/j.isci.2022.104952. https://pubmed.ncbi.nlm.nih.gov/36065190/
4. Fu, Qiqi, Zheng, Hang, Wang, Xia, Liu, Tao, Peng, Jianping. 2024. GINS1 promotes the initiation and progression of bladder cancer by activating the AKT/mTOR/c-Myc signaling pathway. In Experimental cell research, 440, 114125. doi:10.1016/j.yexcr.2024.114125. https://pubmed.ncbi.nlm.nih.gov/38880324/
5. Hou, Shiyang, Zhang, Jie, Chi, Xiaoqian, Kang, Chunbo, Shan, Haifeng. . Roles of DSCC1 and GINS1 in gastric cancer. In Medicine, 102, e35681. doi:10.1097/MD.0000000000035681. https://pubmed.ncbi.nlm.nih.gov/37904396/
6. Zhao, Huanhuan, He, Xiaoxia, Ma, Zhanbei. . Identification of GINS1 as a potential prognostic biomarker for sarcoma using bioinformatic analysis. In Translational cancer research, 12, 1021-1032. doi:10.21037/tcr-23-524. https://pubmed.ncbi.nlm.nih.gov/37180662/
7. Li, Sheng, Wu, Lina, Zhang, Hong, Dong, Bin, Cao, Guang. 2021. GINS1 Induced Sorafenib Resistance by Promoting Cancer Stem Properties in Human Hepatocellular Cancer Cells. In Frontiers in cell and developmental biology, 9, 711894. doi:10.3389/fcell.2021.711894. https://pubmed.ncbi.nlm.nih.gov/34414190/
8. Ma, Luyuan, Li, Rongyang, Li, Pengyong, Si, Libo, Tian, Hui. 2025. GINS1 facilitates the development of lung adenocarcinoma via Wnt/β-catenin activation. In World journal of surgical oncology, 23, 122. doi:10.1186/s12957-025-03786-2. https://pubmed.ncbi.nlm.nih.gov/40197379/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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