C57BL/6JCya-Snord3aem1/Cya
Common Name
Snord3a-KO
Product ID
S-KO-18418
Backgroud
C57BL/6JCya
Strain ID
KOCMP-19850-Snord3a-B6J-VA
Status
When using this mouse strain in a publication, please cite “Snord3a-KO Mouse (Catalog S-KO-18418) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Snord3a-KO
Strain ID
KOCMP-19850-Snord3a-B6J-VA
Gene Name
Snord3a
Product ID
S-KO-18418
Gene Alias
Rnu3a
Background
C57BL/6JCya
Gene Full Name
--
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 10 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000196710
NCBI Transcript ID
NR_002842
Target Region
Exon 1
Size of Effective Region
~0.4 kb
Overview of Gene Research
Snord3a is a small nucleolar RNA that has been implicated in multiple biological processes and disease conditions. It plays roles in pathways related to oxidative stress, inflammation, and may be involved in ribosome biogenesis as small nucleolar RNAs are generally associated with such functions [3,4].
In acute kidney injury (AKI) mouse models, Snord3a deficiency alleviates renal injury. Snord3a regulates the stimulator of interferon genes (STING) signaling axis by promoting STING gene transcription, and its deficiency mitigates STING-associated ferroptosis phenotypes and tubular injury progression. Administration of Snord3a antisense oligonucleotides shows therapeutic advantage in AKI mouse models, highlighting its potential as a prognostic and therapeutic target for AKI [1].
In breast cancer, overexpression of Snord3a specifically sensitizes breast cancer cells to 5-fluorouracil (5-FU) by sponging miR-185-5p to enhance uridine monophosphate synthetase (UMPS) protein expression, suggesting it could be a biomarker and therapeutic target to improve 5-FU-based chemotherapy efficacy [2].
In leukemia, the transcription of Snord3a is increased upon leukemia transformation and enriched in leukemia stem cells. Suppression of Snord3a impairs leukemia cell proliferation and colony-forming capacity in AML cell lines and primary patient samples, with less impact on healthy CD34+ hematopoietic stem and progenitor cells [3].
In conclusion, Snord3a is involved in diverse biological functions across different disease areas. Gene knockout or knockdown models in mice and cell lines have been crucial in revealing its role in AKI, breast cancer, and leukemia, indicating its potential as a biomarker and therapeutic target in these diseases.
References：
1. Zhu, Huanhuan, Wang, Junni, Miao, Jin, Lin, Weiqiang, Han, Fei. 2024. SNORD3A Regulates STING Transcription to Promote Ferroptosis in Acute Kidney Injury. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2400305. doi:10.1002/advs.202400305. https://pubmed.ncbi.nlm.nih.gov/38962954/
2. Luo, Liyun, Zhang, Jianlei, Tang, Hailin, He, Zhimin, Zheng, Guopei. 2020. LncRNA SNORD3A specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression. In Cell death & disease, 11, 329. doi:10.1038/s41419-020-2557-2. https://pubmed.ncbi.nlm.nih.gov/32382150/
3. Yun, Haiyang, Zoller, Julian, Zhou, Fengbiao, Göllner, Stefanie, Müller-Tidow, Carsten. 2024. The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance. In Leukemia, 38, 1688-1698. doi:10.1038/s41375-024-02322-7. https://pubmed.ncbi.nlm.nih.gov/38942785/
4. Cohen, Eran, Avrahami, Dana, Frid, Kati, Lavon, Iris, Gabizon, Ruth. 2013. Snord 3A: a molecular marker and modulator of prion disease progression. In PloS one, 8, e54433. doi:10.1371/journal.pone.0054433. https://pubmed.ncbi.nlm.nih.gov/23349890/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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