C57BL/6JCya-Loxl2em1/Cya
Common Name
Loxl2-KO
Product ID
S-KO-18590
Backgroud
C57BL/6JCya
Strain ID
KOCMP-94352-Loxl2-B6J-VC
When using this mouse strain in a publication, please cite “Loxl2-KO Mouse (Catalog S-KO-18590) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Loxl2-KO
Strain ID
KOCMP-94352-Loxl2-B6J-VC
Gene Name
Product ID
S-KO-18590
Gene Alias
1110004B06Rik, 4930526G11Rik, 9430067E15Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000100420
NCBI RefSeq
NM_033325
Target Region
Exon 3
Size of Effective Region
~0.2 kb
Overview of Gene Research
Loxl2, also known as Lysyl Oxidase Like 2, belongs to the lysyl oxidase (LOX) family. It is a copper and lysine tyrosyl-quinone (LTQ)-dependent amine oxidase. Its canonical function is to catalyze the cross-linking of elastin and collagen in the extracellular matrix (ECM) [4]. It is involved in multiple biological processes and is associated with various diseases, especially cancer and fibrosis [1,2,3,4,6]. Genetically modified mouse models have been crucial for in-depth exploration of its in vivo role [1].
In pancreatic ductal adenocarcinoma (PDAC) mouse models, Loxl2 ablation had little effect on primary tumour development but significantly decreased metastasis and increased overall survival, attributed to non-cell autonomous factors like ECM remodelling. Conversely, Loxl2 overexpression promoted primary and metastatic tumour growth and decreased overall survival, linked to increased epithelial-mesenchymal transition (EMT) and stemness [5].
In conclusion, Loxl2 plays a significant role in processes such as ECM remodelling, EMT, and metastasis. The use of Loxl2 knockout or conditional knockout mouse models has provided valuable insights into its role in cancer, especially in PDAC, highlighting its potential as a therapeutic target in treating metastatic disease [5].
References：
1. Cano, Amparo, Eraso, Pilar, Mazón, María J, Portillo, Francisco. 2023. LOXL2 in Cancer: A Two-Decade Perspective. In International journal of molecular sciences, 24, . doi:10.3390/ijms241814405. https://pubmed.ncbi.nlm.nih.gov/37762708/
2. Cheng, Fang, Yang, Fuji, Wang, Yanjin, Qian, Hui, Yan, Yongmin. 2023. Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway. In Journal of nanobiotechnology, 21, 195. doi:10.1186/s12951-023-01942-y. https://pubmed.ncbi.nlm.nih.gov/37328872/
3. Erasmus, Melisse, Samodien, Ebrahim, Lecour, Sandrine, Pheiffer, Carmen, Johnson, Rabia. 2020. Linking LOXL2 to Cardiac Interstitial Fibrosis. In International journal of molecular sciences, 21, . doi:10.3390/ijms21165913. https://pubmed.ncbi.nlm.nih.gov/32824630/
4. Wen, Bing, Xu, Li-Yan, Li, En-Min. 2020. LOXL2 in cancer: regulation, downstream effectors and novel roles. In Biochimica et biophysica acta. Reviews on cancer, 1874, 188435. doi:10.1016/j.bbcan.2020.188435. https://pubmed.ncbi.nlm.nih.gov/32976981/
5. Alonso-Nocelo, Marta, Ruiz-Cañas, Laura, Sancho, Patricia, Cano, Amparo, Sainz, Bruno. 2022. Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma. In Gut, 72, 345-359. doi:10.1136/gutjnl-2021-325564. https://pubmed.ncbi.nlm.nih.gov/35428659/
6. Puente, Angela, Fortea, Jose Ignacio, Cabezas, Joaquin, Fábrega, Emilio, Crespo, Javier. 2019. LOXL2-A New Target in Antifibrogenic Therapy? In International journal of molecular sciences, 20, . doi:10.3390/ijms20071634. https://pubmed.ncbi.nlm.nih.gov/30986934/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.