C57BL/6JCya-Tasor2em1/Cya
Common Name:
Tasor2-KO
Product ID:
S-KO-18631
Background:
C57BL/6JCya
Product Type
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Basic Information
Strain Name
Tasor2-KO
Strain ID
KOCMP-105203-Tasor2-B6J-VB
Gene Name
Product ID
S-KO-18631
Gene Alias
Fam208b; Pap20; mKIAA2006
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tasor2em1/Cya mice (Catalog S-KO-18631) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000096069
NCBI RefSeq
NM_134063
Target Region
Exon 6~9
Size of Effective Region
~4.4 kb
Detailed Document
Overview of Gene Research
Tasor2 is a paralog of TASOR, and it serves as the core of the HUSH2 complex. The HUSH2 complex is involved in repressing interferon-stimulated genes, with the transcription factor IRF2 recruiting HUSH2 for this purpose. This process is part of the intricate genome defense mechanism that links epigenetic regulation with the immune response [1].
Two studies have identified the HUSH2 complex centered around Tasor2. These studies show that HUSH and HUSH2 localize to distinct genomic loci. HUSH2 targets and represses KRAB-ZNFs and interferon signaling and response genes. By using in silico protein structure predictions and amino acid substitutions to disrupt MPP8 binding to HUSH complexes, it was found that the relative quantities of HUSH and HUSH2 complexes are important in regulating LINE-1 element activity. Also, dynamic changes in TASOR and Tasor2 expression help cells finely tune HUSH-mediated silencing [2,3].
In conclusion, Tasor2, as the core of the HUSH2 complex, plays a crucial role in repressing interferon-stimulated genes and is involved in the regulation of retrotransposon silencing. The study of Tasor2 through methods like in silico protein structure prediction and amino acid substitution experiments has provided insights into the interplay between HUSH complexes, which is important for understanding the epigenetic and immune aspects of genome defense.
References:
1. Danac, Joshua Miguel C, Matthews, Rachael E, Gungi, Akhila, Timms, Richard T, Tchasovnikarova, Iva A. 2024. Competition between two HUSH complexes orchestrates the immune response to retroelement invasion. In Molecular cell, 84, 2870-2881.e5. doi:10.1016/j.molcel.2024.06.020. https://pubmed.ncbi.nlm.nih.gov/39013473/
2. Jensvold, Zena D, Flood, Julia R, Christenson, Anna E, Lewis, Peter W. 2024. Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing. In Nature communications, 15, 9492. doi:10.1038/s41467-024-53761-w. https://pubmed.ncbi.nlm.nih.gov/39489739/
3. Jensvold, Zena D, Christenson, Anna E, Flood, Julia R, Lewis, Peter W. 2024. Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.12.28.573526. https://pubmed.ncbi.nlm.nih.gov/38313255/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen