C57BL/6JCya-Pspc1em1/Cya
Common Name
Pspc1-KO
Product ID
S-KO-18870
Backgroud
C57BL/6JCya
Strain ID
KOCMP-66645-Pspc1-B6J-VB
When using this mouse strain in a publication, please cite “Pspc1-KO Mouse (Catalog S-KO-18870) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pspc1-KO
Strain ID
KOCMP-66645-Pspc1-B6J-VB
Gene Name
Product ID
S-KO-18870
Gene Alias
5730470C09Rik, PSP1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000022507
NCBI RefSeq
NM_025682
Target Region
Exon 2
Size of Effective Region
~1.5 kb
Overview of Gene Research
PSPC1, also known as Paraspeckle component 1, is involved in multiple biological processes. It plays a role in nucleocytoplasmic shuttling, which is dysregulated in cancers and is emerging as a cancer hallmark. It also participates in pathways related to tumor progression, stem cell bivalency regulation, and cell adhesion and motility. Understanding PSPC1 through genetic models is crucial for uncovering its functions in health and disease [1,2,5,6].
In hepatocellular carcinoma (HCC) progression, PSPC1 is the contextual determinant of the TGF-β prometastatic switch and PTK6/β -catenin reciprocal oncogenic nucleocytoplasmic shuttling. The PSPC1 C -terminal 131 polypeptide (PSPC1 -CT131) targeting PSPC1 and PTK6 has tumor -suppressive effects in HCC cells and mouse models [1]. In prostate cancer, PSPC1 is up -regulated in primary and metastatic tumors, and its elevated expression correlates with poor prognosis [3]. In acute myeloid leukemia (AML), PSPC1 is aberrantly overexpressed. PSPC1 loss in human AML cells and mouse models induces differentiation, suppresses proliferation, and abolishes leukemogenesis [4].
In conclusion, PSPC1 is a significant factor in multiple disease -related biological processes, especially in cancer progression. Studies using mouse models have revealed its oncogenic roles in HCC, prostate cancer, and AML, highlighting its potential as a therapeutic target in these diseases.
References：
1. Lang, Yaw-Dong, Jou, Yuh-Shan. 2021. PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression. In Journal of biomedical science, 28, 57. doi:10.1186/s12929-021-00753-3. https://pubmed.ncbi.nlm.nih.gov/34340703/
2. Lang, Yaw-Dong, Jou, Yuh-Shan. 2020. PSPC1: a contextual determinant of tumor progression. In Molecular & cellular oncology, 7, 1721253. doi:10.1080/23723556.2020.1721253. https://pubmed.ncbi.nlm.nih.gov/32158931/
3. Lemster, Anna-Lena, Weingart, Anika, Bottner, Justus, Offermann, Anne, Kirfel, Jutta. 2023. Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer. In Human pathology, 138, 1-11. doi:10.1016/j.humpath.2023.05.007. https://pubmed.ncbi.nlm.nih.gov/37209920/
4. Hong, Juyeong, Sui, Pinpin, Li, Ying, Wang, Jianlong, Xu, Mingjiang. 2025. PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. In Cell stem cell, 32, 463-478.e6. doi:10.1016/j.stem.2025.01.010. https://pubmed.ncbi.nlm.nih.gov/39954676/
5. Huang, Xin, Bashkenova, Nazym, Hong, Yantao, Zhou, Hongwei, Wang, Jianlong. . A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. In Cell reports, 39, 110928. doi:10.1016/j.celrep.2022.110928. https://pubmed.ncbi.nlm.nih.gov/35675764/
6. Jen, Hsin-Wei, Gu, De-Leung, Lang, Yaw-Dong, Jou, Yuh-Shan. 2020. PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. In Cells, 9, . doi:10.3390/cells9061490. https://pubmed.ncbi.nlm.nih.gov/32570949/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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