C57BL/6JCya-Ptgdsem1/Cya
Common Name:
Ptgds-KO
Product ID:
S-KO-18883
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ptgds-KO
Strain ID
KOCMP-19215-Ptgds-B6J-VB
Gene Name
Product ID
S-KO-18883
Gene Alias
21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ptgdsem1/Cya mice (Catalog S-KO-18883) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000015234
NCBI RefSeq
NM_008963
Target Region
Exon 2~3
Size of Effective Region
~0.3 kb
Detailed Document
Overview of Gene Research
Ptgds, or prostaglandin D2 synthase, is a glycoprotein belonging to the lipocalin superfamily. It plays dual roles in prostaglandins metabolism and lipid transport, and is involved in various cellular processes [1,2]. It may be associated with pathways like Wnt-β-catenin-STAT3, and has significance in biological processes related to cell proliferation, apoptosis, and cell cycle regulation [1].
In multiple cancers, its role has been explored. In diffuse large B-cell lymphoma (DLBCL), high Ptgds expression correlated with poor prognosis, and its knockdown or treatment with inhibitor AT56 exerted anti-tumor effects by regulating cell functions and enhancing drug sensitivity, possibly through MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling [1]. In peripheral T cell lymphoma (PTCL), high Ptgds expression was linked to poor prognosis, and its knockdown and AT56 treatment inhibited PTCL progression and promoted ferroptosis by regulating HMOX1-mediated iron metabolism [3]. In cervical squamous cell carcinoma, PTGDS showed low expression, and it was an independent prognostic indicator [4]. In medulloblastoma, low PTGDS expression was associated with a lower 3-year survival rate [5]. In endometrial cancer, decreased PTGDS expression predicted poor survival, and it may be involved in the adaptive immune response, leukocyte migration, and regulation of cell adhesion molecules and chemokine signaling [6]. In prostate adenocarcinoma, overexpression of PTGDS suppressed cell migration, invasion, and proliferation [7]. Also, in aminoglycoside-induced vestibular dysfunction, Ptgds knockdown protected vestibular hair cells [2]. In a Parkinson's disease mouse model, MLKL deficiency led to downregulated Ptgds expression, reduced microglial cells, and dampened neuron death [8]. In rosacea, knockdown of Ptgds in fibroblasts blocked rosacea development in mice [9].
In summary, Ptgds is involved in diverse biological processes with implications in multiple disease areas. Gene knockdown and inhibitor studies, similar to those in KO mouse models, have revealed its roles in cancer progression, vestibular hair cell protection, and neurodegenerative disease-related inflammation. Understanding Ptgds can potentially offer new therapeutic strategies for these diseases.
References:
1. Hu, Shunfeng, Ren, Shuai, Cai, Yiqing, Zhou, Xiangxiang, Wang, Xin. 2021. Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling. In Cell death and differentiation, 29, 642-656. doi:10.1038/s41418-021-00880-2. https://pubmed.ncbi.nlm.nih.gov/34743203/
2. Chen, Chen, Zhao, Zhimin, Han, Jinghong, Zhang, Yue, Nie, Guohui. 2025. Ptgds downregulation protect vestibular hair cells from aminoglycoside-induced vestibulotoxicity. In PloS one, 20, e0320634. doi:10.1371/journal.pone.0320634. https://pubmed.ncbi.nlm.nih.gov/40198625/
3. Hu, Shunfeng, Liu, Bingyu, Shang, Juanjuan, Zhou, Xiangxiang, Wang, Xin. 2024. Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism. In British journal of cancer, 132, 384-400. doi:10.1038/s41416-024-02919-w. https://pubmed.ncbi.nlm.nih.gov/39706989/
4. Jiang, Pinping, Cao, Ying, Gao, Feng, Xie, Manxin, Fu, Shilong. 2021. SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma. In BMC cancer, 21, 694. doi:10.1186/s12885-021-08212-w. https://pubmed.ncbi.nlm.nih.gov/34116656/
5. Ren, Zhangping, Gao, Ming, Jiang, Wei. 2022. Prognostic role of NLGN2 and PTGDS in medulloblastoma based on gene expression omnibus. In American journal of translational research, 14, 3769-3782. doi:. https://pubmed.ncbi.nlm.nih.gov/35836891/
6. Zou, Ruoyao, Zheng, Mingjun, Tan, Mingzi, Luan, Nannan, Zhu, Liancheng. 2020. Decreased PTGDS Expression Predicting Poor Survival of Endometrial Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Immunohistochemical Validation. In Cancer management and research, 12, 5057-5075. doi:10.2147/CMAR.S255753. https://pubmed.ncbi.nlm.nih.gov/32617019/
7. Chen, Bohong, Guo, Li, Wang, Lihui, Wu, Dapeng, Du, Yuefeng. 2024. Leveraging cell death patterns to predict metastasis in prostate adenocarcinoma and targeting PTGDS for tumor suppression. In Scientific reports, 14, 21680. doi:10.1038/s41598-024-72985-w. https://pubmed.ncbi.nlm.nih.gov/39289451/
8. Geng, Lu, Gao, Wenqing, Saiyin, Hexige, Zhang, Zhuohua, Li, Jixi. 2023. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease. In Molecular neurodegeneration, 18, 94. doi:10.1186/s13024-023-00686-5. https://pubmed.ncbi.nlm.nih.gov/38041169/
9. Chen, Mengting, Yang, Li, Zhou, Peijie, Deng, Zhili, Li, Ji. 2024. Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea. In Nature communications, 15, 8737. doi:10.1038/s41467-024-52946-7. https://pubmed.ncbi.nlm.nih.gov/39384741/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen