C57BL/6JCya-Hpdem1/Cya
Common Name
Hpd-KO
Product ID
S-KO-19008
Backgroud
C57BL/6JCya
Strain ID
KOCMP-15445-Hpd-B6J-VB
Status
When using this mouse strain in a publication, please cite “Hpd-KO Mouse (Catalog S-KO-19008) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Hpd-KO
Strain ID
KOCMP-15445-Hpd-B6J-VB
Gene Name
Product ID
S-KO-19008
Gene Alias
Fla, Flp, Laf, Hppd, 4HPPD
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000031398
NCBI RefSeq
NM_008277
Target Region
Exon 7~9
Size of Effective Region
~2.8 kb
Overview of Gene Research
Hpd, also known as 4-hydroxyphenylpyruvate dioxygenase, is a critical enzyme in tyrosine metabolism. It catalyzes the conversion of 4-hydroxyphenylpyruvate to homogeneous acids in liver tissues [2,3]. This metabolic process is essential for maintaining normal physiological functions, and its disruption can lead to various health issues.
In breast cancer, HPD overexpression is positively correlated with histological grade and clinical stage, and inversely correlated with 10-year overall survival rates, indicating it may be a prognostic predictor and potential therapeutic target [1]. In hepatocellular carcinoma (HCC), HPD mRNA and protein expression are dramatically reduced, and low HPD expression is correlated with larger tumor size, advanced TNM staging, and poor differentiation. Knockdown of HPD increases HCC cell growth and motility, suggesting HPD may serve as a tumor suppressor and prognostic marker for HCC patients [3]. Ttc36-/-mice, which have reduced HPD expression in the liver, exhibit tyrosinemia, damage to hippocampal neurons, and learning and memory deficits, revealing the significance of the TTC36-STK33-PELI1-regulated HPD expression in tyrosinemia and associated neurological disorders [2].
In conclusion, Hpd plays a crucial role in tyrosine metabolism. Its dysregulation is associated with breast cancer and HCC, with implications for prognosis and treatment. The Ttc36-/-mouse model has provided insights into the role of Hpd in tyrosinemia and neurological damage, highlighting the importance of Hpd in maintaining normal physiological functions and its potential as a therapeutic target in related diseases.
References：
1. Wang, Xuanyu, Shang, Yongjun, Yang, Lina, Shan, Changliang, Liu, Shuangping. 2019. HPD overexpression predicts poor prognosis in breast cancer. In Pathology, research and practice, 215, 152524. doi:10.1016/j.prp.2019.152524. https://pubmed.ncbi.nlm.nih.gov/31277952/
2. Xie, Yajun, Lv, Xiaoyan, Ni, Dongsheng, Lu, Zhimin, Zhou, Qin. 2019. HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. In Nature communications, 10, 4266. doi:10.1038/s41467-019-12011-0. https://pubmed.ncbi.nlm.nih.gov/31537781/
3. Yang, Xia, Chen, Shi-Lu, Lin, Cen-Shan, Wang, Chun-Hua, Yun, Jing-Ping. 2020. Tyrosine metabolic enzyme HPD is decreased and predicts unfavorable outcomes in hepatocellular carcinoma. In Pathology, research and practice, 216, 153153. doi:10.1016/j.prp.2020.153153. https://pubmed.ncbi.nlm.nih.gov/32891822/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.