C57BL/6NCya-Hampem1/Cya
Common Name:
Hamp-KO
Product ID:
S-KO-19161
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Hamp-KO
Strain ID
KOCMP-84506-Hamp-B6N-VA
Gene Name
Product ID
S-KO-19161
Gene Alias
Hamp1; Hepc; Hepc1
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Hampem1/Cya mice (Catalog S-KO-19161) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000062620
NCBI RefSeq
NM_032541
Target Region
Exon 1~3
Size of Effective Region
~2.6 kb
Detailed Document
Overview of Gene Research
Hamp, also known as Hepcidin antimicrobial peptide, is a gene encoding a peptide hormone crucial for regulating systemic iron homeostasis [1,4,5,6]. It binds to ferroportin, an iron exporter, leading to its internalization and degradation, thus controlling the concentration of ferroportin on the cell surface and completing an iron-regulating homeostatic loop [5].
In gastric cancer, high HAMP expression is associated with poor overall survival and is related to sex, tumor stage, and immune cell infiltration levels, suggesting it may serve as an independent prognostic biomarker through the immune pathway [1]. In non-small cell lung cancer, HAMP promotes cell proliferation, invasion, and migration by activating the NF-κB pathway, and this is negatively modulated by miR-873-5p [2]. In hepatocellular carcinoma, HAMP shows potential as a diagnostic, PD-(L)1 immunotherapy sensitivity, and prognostic biomarker, being positively correlated with immune cell infiltration and immune checkpoint expression [3]. In type 2 diabetes, epigenetic changes in HAMP may be an early marker, with decreased expression in diabetes-prone mice due to increased DNA methylation [6].
In conclusion, Hamp plays a vital role in iron metabolism and is associated with multiple diseases such as gastric cancer, non-small cell lung cancer, hepatocellular carcinoma, and type 2 diabetes. Research on Hamp, including through gene-based models, helps to understand the underlying mechanisms of these diseases and may provide new diagnostic and therapeutic strategies.
References:
1. Yang, Jing, Wei, Hui, Liu, Mengxiao, Wang, Yuping, Zhou, Yongning. 2022. Prognostic biomarker HAMP and associates with immune infiltration in gastric cancer. In International immunopharmacology, 108, 108839. doi:10.1016/j.intimp.2022.108839. https://pubmed.ncbi.nlm.nih.gov/35576847/
2. Li, Zhifeng, Liu, Jinglei, Wang, Ping, He, Guanghui, Yang, Liwei. 2024. HAMP predicts a pivotal role in modulating the malignant behaviors of non-small cell lung cancer cells. In Aging, 16, 8524-8540. doi:10.18632/aging.205819. https://pubmed.ncbi.nlm.nih.gov/38787358/
3. Chen, Guoming, Zhang, Cheng, Li, Danyun, Wang, Ning, Feng, Yibin. 2023. HAMP as a Potential Diagnostic, PD-(L)1 Immunotherapy Sensitivity and Prognostic Biomarker in Hepatocellular Carcinoma. In Biomolecules, 13, . doi:10.3390/biom13020360. https://pubmed.ncbi.nlm.nih.gov/36830729/
4. Hentze, Matthias W, Muckenthaler, Martina U, Galy, Bruno, Camaschella, Clara. . Two to tango: regulation of Mammalian iron metabolism. In Cell, 142, 24-38. doi:10.1016/j.cell.2010.06.028. https://pubmed.ncbi.nlm.nih.gov/20603012/
5. Nemeth, Elizabeta, Tuttle, Marie S, Powelson, Julie, Ganz, Tomas, Kaplan, Jerry. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. In Science (New York, N.Y.), 306, 2090-3. doi:. https://pubmed.ncbi.nlm.nih.gov/15514116/
6. Ouni, Meriem, Eichelmann, Fabian, Jähnert, Markus, Schulze, Matthias B, Schürmann, Annette. 2023. Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes. In Molecular metabolism, 75, 101774. doi:10.1016/j.molmet.2023.101774. https://pubmed.ncbi.nlm.nih.gov/37429525/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen