C57BL/6JCya-Zc3hav1lem1/Cya
Common Name:
Zc3hav1l-KO
Product ID:
S-KO-19463
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zc3hav1l-KO
Strain ID
KOCMP-209032-Zc3hav1l-B6J-VC
Gene Name
Product ID
S-KO-19463
Gene Alias
B130055L09Rik; E430016P22Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zc3hav1lem1/Cya mice (Catalog S-KO-19463) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000058524
NCBI RefSeq
NM_172467
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Zc3hav1l is a gene that has been associated with various biological aspects. While its specific essential function and associated pathways are not comprehensively detailed in the provided references, studies suggest its potential importance in different biological processes. Genetic models could potentially be valuable for further understanding its function.
In humans, an interchromosomal RNA fusion between ZC3HAV1L and CHMP1A was computationally detected in normal human mammary epithelial cells and experimentally confirmed in multiple cells and tissues, with three variants of the chimeric RNA detected, indicating complex splicing likely through trans-splicing [1]. In pigs, a nonsense mutation in Zc3hav1l on SSC18 was found to have a direct effect on lean meat percentage, suggesting its role in porcine leanness regulation [2]. In colon cancer, a risk score system including ZC3HAV1L was constructed to predict prognosis, though the exact role of Zc3hav1l in the cancer's biology from this study is not clearly isolated [3].
In conclusion, Zc3hav1l seems to be involved in processes such as RNA splicing in humans, regulation of lean meat percentage in pigs, and potentially in colon cancer prognosis. Although no gene knockout or conditional knockout mouse models were mentioned in the references, these could be useful in further elucidating its function in these and potentially other disease-related or biological processes.
References:
1. Fang, Wenwen, Wei, Yong, Kang, Yibin, Landweber, Laura F. 2012. Detection of a common chimeric transcript between human chromosomes 7 and 16. In Biology direct, 7, 49. doi:10.1186/1745-6150-7-49. https://pubmed.ncbi.nlm.nih.gov/23273016/
2. Ibragimov, Emil, Pedersen, Anni Øyan, Sloth, Niels Morten, Fredholm, Merete, Karlskov-Mortensen, Peter. 2024. Identification of a novel QTL for lean meat percentage using imputed genotypes. In Animal genetics, 55, 658-663. doi:10.1111/age.13442. https://pubmed.ncbi.nlm.nih.gov/38752377/
3. Zhang, Jun-Rong, Hou, Ping, Wang, Xiao-Jie, Huang, Zheng-Yuan, Chen, Xian-Qiang. 2021. TNFRSF11B Suppresses Memory CD4+ T Cell Infiltration in the Colon Cancer Microenvironment: A Multiomics Integrative Analysis. In Frontiers in immunology, 12, 742358. doi:10.3389/fimmu.2021.742358. https://pubmed.ncbi.nlm.nih.gov/34938284/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen