C57BL/6JCya-Ptger1em1/Cya
Common Name:
Ptger1-KO
Product ID:
S-KO-19819
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ptger1-KO
Strain ID
KOCMP-19216-Ptger1-B6J-VB
Gene Name
Product ID
S-KO-19819
Gene Alias
EP1; Ptgerep1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ptger1em1/Cya mice (Catalog S-KO-19819) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019608
NCBI RefSeq
NM_013641
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Ptger1, also known as the E-prostanoid 1 receptor, is a G-protein coupled receptor that binds prostaglandin E2 (PGE2). It is involved in multiple signaling pathways and plays important roles in various biological processes. PGE2/PTGER1 axis can regulate anti-oxidative gene expression through the PKC/Nrf2 cascade, and is associated with processes like cell survival, ferroptosis regulation, and inflammation-related responses [1].
In diabetic mouse models, PTGER1 deletion attenuated renal injury, including albuminuria, mesangial matrix expansion, and glomerular hypertrophy. This indicates that PTGER1 activation contributes to the progression of diabetic nephropathy in podocytes, proximal tubules, and the vasculature [2]. In addition, maternal protein restriction during pregnancy led to a positive correlation between DNA hypermethylation of renal Ptger1 and its high mRNA expression in offspring, suggesting an epigenetic link to disease susceptibility [3,4].
In conclusion, Ptger1 is a crucial receptor in mediating PGE2-related biological functions. Studies using gene knockout mouse models have revealed its role in diabetic nephropathy and the impact of prenatal nutritional factors on its epigenetic regulation. These findings contribute to our understanding of the underlying mechanisms of related diseases and may provide potential therapeutic targets.
References:
1. Wang, Bei, Jin, Yuxuan, Liu, Jiao, Zuo, Shengkai, Yu, Ying. 2023. EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2. In Redox biology, 65, 102825. doi:10.1016/j.redox.2023.102825. https://pubmed.ncbi.nlm.nih.gov/37531930/
2. Thibodeau, Jean-François, Nasrallah, Rania, Carter, Anthony, Hébert, Richard L, Kennedy, Christopher R J. 2013. PTGER1 deletion attenuates renal injury in diabetic mouse models. In The American journal of pathology, 183, 1789-1802. doi:10.1016/j.ajpath.2013.08.022. https://pubmed.ncbi.nlm.nih.gov/24113456/
3. Jia, Huijuan, Miyoshi, Moe, Li, Xuguang, Ito, Takashi, Kato, Hisanori. 2023. The Epigenetic Legacy of Maternal Protein Restriction: Renal Ptger1 DNA Methylation Changes in Hypertensive Rat Offspring. In Nutrients, 15, . doi:10.3390/nu15183957. https://pubmed.ncbi.nlm.nih.gov/37764741/
4. Miyoshi, Moe, Sato, Masayuki, Saito, Kenji, Jia, Huijuan, Kato, Hisanori. 2018. Maternal Protein Restriction Alters the Renal Ptger1 DNA Methylation State in SHRSP Offspring. In Nutrients, 10, . doi:10.3390/nu10101436. https://pubmed.ncbi.nlm.nih.gov/30301128/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen