C57BL/6JCya-Dscc1em1/Cya
Common Name:
Dscc1-KO
Product ID:
S-KO-20080
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Dscc1-KO
Strain ID
KOCMP-72107-Dscc1-B6J-VB
Gene Name
Product ID
S-KO-20080
Gene Alias
2010006I05Rik; 2600005O03Rik; Dcc1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
15
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dscc1em1/Cya mice (Catalog S-KO-20080) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000110231
NCBI RefSeq
NM_001355594
Target Region
Exon 2
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
Dscc1, or DNA replication and sister chromatid cohesion 1, is involved in DNA replication, repair, and sister chromatid cohesion (SCC) as a component of the alternative replication factor C (RFC) complex [6]. It also plays a role in the DNA double-strand break (DSB) repair pathway choice, promoting homologous recombination (HR) repair during the S/G2 phase [5].
In mouse mutant lines, null mice for Dscc1 showed a significant increase in micronucleus (MN) formation, along with phenotypes characteristic of patients with cohesinopathy disorders [1]. In human cancers, high DSCC1 expression is associated with poor prognosis in lung adenocarcinoma (LUAD), gastric cancer, and breast cancer [2,4,10]. In LUAD, it promotes cell proliferation, stemness, EMT, and metastatic potential, and interacts with HSP90AB1 to regulate ER stress [3]. In gastric cancer, transcription factor E2F4 upregulates DSCC1 expression, promoting cell proliferation, migration, and invasion [7]. Also, multi-omics analyses suggest its potential as a pan-cancer biomarker and therapeutic target [8,9].
In conclusion, Dscc1 is crucial for maintaining genomic stability through its functions in DNA-related processes. Mouse models with Dscc1 knockout have revealed its role in conditions related to genomic instability, such as micronucleus formation and phenotypes similar to cohesinopathy disorders. In the context of cancer, high DSCC1 expression is often associated with poor prognosis and cancer progression, indicating its potential as a biomarker and therapeutic target in multiple cancer types.
References：
1. Adams, D J, Barlas, B, McIntyre, R E, Jackson, S P, Balmus, G. 2024. Genetic determinants of micronucleus formation in vivo. In Nature, 627, 130-136. doi:10.1038/s41586-023-07009-0. https://pubmed.ncbi.nlm.nih.gov/38355793/
2. Chang, Sisi, Zhu, Yahui, Xi, Yutan, Ma, Chunzheng, Li, Honglin. 2021. High DSCC1 Level Predicts Poor Prognosis of Lung Adenocarcinoma. In International journal of general medicine, 14, 6961-6974. doi:10.2147/IJGM.S329482. https://pubmed.ncbi.nlm.nih.gov/34707388/
3. Lin, Xu, Liu, Ye-Han, Zhang, Huan-Qi, Li, Yang-Ling, Hu, Jian. 2023. DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress. In Cancer cell international, 23, 208. doi:10.1186/s12935-023-03047-w. https://pubmed.ncbi.nlm.nih.gov/37742009/
4. Hou, Shiyang, Zhang, Jie, Chi, Xiaoqian, Kang, Chunbo, Shan, Haifeng. . Roles of DSCC1 and GINS1 in gastric cancer. In Medicine, 102, e35681. doi:10.1097/MD.0000000000035681. https://pubmed.ncbi.nlm.nih.gov/37904396/
5. Tian, Jiaxin, Li, Jiaheng, Liu, Fengqi, Zhang, Haoxing, Chen, Guo. 2025. DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair. In Cell reports, 44, 115452. doi:10.1016/j.celrep.2025.115452. https://pubmed.ncbi.nlm.nih.gov/40117291/
6. van Schie, Janne Jm, de Lint, Klaas, Pai, Govind M, Wolthuis, Rob Mf, de Lange, Job. 2022. MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC. In Life science alliance, 6, . doi:10.26508/lsa.202201596. https://pubmed.ncbi.nlm.nih.gov/36622344/
7. Baral, Shantanu, Yu, Yantao, Sun, Qiannan, Wang, Sen, Wang, Daorong. 2024. Transcription Factor E2F4 Promote Proliferation, Migration, and Invasion of Gastric Cancer Cells by transcriptionally activating DSCC1. In International journal of biological sciences, 20, 4978-4998. doi:10.7150/ijbs.99590. https://pubmed.ncbi.nlm.nih.gov/39309429/
8. Wang, Jingru, Gilani, Sana Fatima, Noor, Nazia, Hassan, Syed Sairum, Hameed, Yasir. 2024. Decoding the DSCC1 gene as a pan-cancer biomarker in human cancers via comprehensive multi-omics analyses. In American journal of translational research, 16, 738-754. doi:10.62347/YORR3755. https://pubmed.ncbi.nlm.nih.gov/38586115/
9. Cheng, Wei, Lin, Peng. 2025. DSCC1 Identified as Promising Tumor Biomarker and Potential Therapeutic Target Through Comprehensive Multi-omics Analysis and Experimental Validation. In Molecular biotechnology, , . doi:10.1007/s12033-025-01404-w. https://pubmed.ncbi.nlm.nih.gov/39992486/
10. Aljohani, Abrar I. 2024. Prognostic Significance of DSCC1, a Biomarker Associated with Aggressive Features of Breast Cancer. In Medicina (Kaunas, Lithuania), 60, . doi:10.3390/medicina60121929. https://pubmed.ncbi.nlm.nih.gov/39768811/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen