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C57BL/6JCya-Lcorlem1/Cya
Common Name:
Lcorl-KO
Product ID:
S-KO-20345
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Lcorl-KO
Strain ID
KOCMP-209707-Lcorl-B6J-VA
Gene Name
Lcorl
Product ID
S-KO-20345
Gene Alias
Mlr1
Background
C57BL/6JCya
NCBI ID
209707
Modification
Conventional knockout
Chromosome
5
Phenotype
MGI:2651932
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lcorlem1/Cya mice (Catalog S-KO-20345) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000016026
NCBI RefSeq
NM_001163073
Target Region
Exon 7
Size of Effective Region
~1.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Lcorl, or ligand-dependent corepressor-like, is a gene strongly associated with metabolic traits, especially body size, glucose homeostasis, and growth in humans and livestock [1,2,3,4,5,6,7,8]. Genome-wide association studies (GWAS) have identified it as a key locus related to these characteristics, yet its functional mechanisms were unclear until detailed research was carried out [1].

In Lcorl knockout mice (Lcorl-/-), the pups are born smaller, but reach normal weight by 7-9 weeks. As they age, these mice remain lean with decreased daily food intake. Their glucose tolerance and insulin sensitivity are improved. Mechanistically, the stunted growth is linked to reduced circulating IGF-1 levels, and the expression of genes downstream of GH signaling, as well as those involved in glucose and lipid metabolism, are altered in the liver. Also, Lcorl-/-mice are protected against high-fat diet challenges but show reduced exercise capacity [1].

In conclusion, Lcorl plays a crucial role in regulating growth and metabolism. The Lcorl knockout mouse model has been instrumental in revealing its function in growth, body weight regulation, glucose homeostasis, and response to diet challenges, providing valuable insights into the gene's role in metabolic-related processes and potentially related diseases [1].

References:
1. Wyler, Steven C, Gahlot, Surbhi, Bideyan, Lara, Fujikawa, Teppei, Elmquist, Joel K. . LCoRL Regulates Growth and Metabolism. In Endocrinology, 165, . doi:10.1210/endocr/bqae146. https://pubmed.ncbi.nlm.nih.gov/39467326/
2. Takasuga, Akiko. 2015. PLAG1 and NCAPG-LCORL in livestock. In Animal science journal = Nihon chikusan Gakkaiho, 87, 159-67. doi:10.1111/asj.12417. https://pubmed.ncbi.nlm.nih.gov/26260584/
3. Saif, Rashid, Henkel, Jan, Jagannathan, Vidhya, Flury, Christine, Leeb, Tosso. 2020. The LCORL Locus is under Selection in Large-Sized Pakistani Goat Breeds. In Genes, 11, . doi:10.3390/genes11020168. https://pubmed.ncbi.nlm.nih.gov/32033434/
4. Yang, Yunzhou, Wang, Cui, Li, Guangquan, Wang, Huiying, He, Daqian. 2023. Significant association of mutations close to LCORL gene with growth performance in Zhedong white geese (Anser cygnoides). In Animal genetics, 54, 628-631. doi:10.1111/age.13342. https://pubmed.ncbi.nlm.nih.gov/37381668/
5. Bai, Fengting, Cai, Yudong, Qi, Min, Lenstra, Johannes A, Jiang, Yu. 2025. LCORL and STC2 Variants Increase Body Size and Growth Rate in Cattle and Other Animals. In Genomics, proteomics & bioinformatics, , . doi:10.1093/gpbjnl/qzaf025. https://pubmed.ncbi.nlm.nih.gov/40094447/
6. Wang, Tianqi, Shi, Xiaoyuan, Liu, Ziwen, Wang, Changfa, Chai, Wenqiong. 2022. A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey. In Animals : an open access journal from MDPI, 12, . doi:10.3390/ani12192581. https://pubmed.ncbi.nlm.nih.gov/36230323/
7. Majeres, Leif E, Dilger, Anna C, Shike, Daniel W, McCann, Joshua C, Beever, Jonathan E. 2024. Defining a Haplotype Encompassing the LCORL-NCAPG Locus Associated with Increased Lean Growth in Beef Cattle. In Genes, 15, . doi:10.3390/genes15050576. https://pubmed.ncbi.nlm.nih.gov/38790206/
8. Metzger, Julia, Schrimpf, Rahel, Philipp, Ute, Distl, Ottmar. 2013. Expression levels of LCORL are associated with body size in horses. In PloS one, 8, e56497. doi:10.1371/journal.pone.0056497. https://pubmed.ncbi.nlm.nih.gov/23418579/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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