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Cd34-Dre
Product ID:
I001068
Strain:
C57BL/6JCya
Status:
Description:
The coding sequence of exon 1 plus partial intron 1 was replaced with "Dre-rBG pA" cassette.
The coding sequence of exon 1 plus partial intron 1 was replaced with "Dre-rBG pA" cassette.
Cd68-loxP-Stop-loxP-DTR
Product ID:
C001750
Strain:
C57BL/6JCya
Status:
Description:
The loxP-3*SV40 pA-loxP-IRES-DTR-rBG pA cassette was inserted ~30 bp downstream of the TGA stop codon. Upstream of the DTR (diphtheria toxin receptor) gene lies a loxP-Stop-loxP cassette that blocks DTR transcription and expression. Upon Cre recombination, Cre-mediated deletion of the loxP-flanked stop (LSL) element enables DTR expression in Cre-positive cells. Intravenous administration of diphtheria toxin (DT) then selectively ablates these cells.
The loxP-3*SV40 pA-loxP-IRES-DTR-rBG pA cassette was inserted ~30 bp downstream of the TGA stop codon. Upstream of the DTR (diphtheria toxin receptor) gene lies a loxP-Stop-loxP cassette that blocks DTR transcription and expression. Upon Cre recombination, Cre-mediated deletion of the loxP-flanked stop (LSL) element enables DTR expression in Cre-positive cells. Intravenous administration of diphtheria toxin (DT) then selectively ablates these cells.
Cd7-Furin-GSG-T2A-Dre
Product ID:
I001084
Strain:
C57BL/6JCya
Status:
Description:
The TGA stop codon was replaced with "Furin-GSG-T2A-Dre" cassette.
The TGA stop codon was replaced with "Furin-GSG-T2A-Dre" cassette.
Itgax-Dre
Product ID:
C001662
Strain:
C57BL/6JCya
Status:
Description:
The TGA stop codon was replaced with the "P2A-Dre" cassette. Dre recombinase is expressed under the regulatory control of Itgax gene elements, without impacting the endogenous expression of the Itgax gene.
The TGA stop codon was replaced with the "P2A-Dre" cassette. Dre recombinase is expressed under the regulatory control of Itgax gene elements, without impacting the endogenous expression of the Itgax gene.
Kit-LSL-T2A-DTR-P2A-Dre
Product ID:
I001102
Strain:
C57BL/6JCya
Status:
Description:
The TGA stop codon was replaced with the "loxP-6*SV40 pA-loxP-T2A-DTR-P2A-Dre" cassette.
The TGA stop codon was replaced with the "loxP-6*SV40 pA-loxP-T2A-DTR-P2A-Dre" cassette.
RC-LR-DTR
Product ID:
I001040
Strain:
C57BL/6JCya
Status:
Description:
RC-LR-DTR mice are generated by combining the DTR system with the Cre-loxP and Dre-rox conditional recombinase systems. When these mice are crossed with Cre and Dre mice, DTR can be expressed specifically in tissues to induce tissue- and cell-specific ablation. Heterozygous RC-LR-DTR mice are viable and fertile, and homozygous RC-LR-DTR mice are also viable.
RC-LR-DTR mice are generated by combining the DTR system with the Cre-loxP and Dre-rox conditional recombinase systems. When these mice are crossed with Cre and Dre mice, DTR can be expressed specifically in tissues to induce tissue- and cell-specific ablation. Heterozygous RC-LR-DTR mice are viable and fertile, and homozygous RC-LR-DTR mice are also viable.
Trhr-Flpo
Product ID:
C001679
Strain:
C57BL/6JCya
Status:
Description:
The "P2A-Flpo" cassette was inserted upstream of TAA stop codon. Flpo recombinase is expressed under the regulatory control of Trhr gene elements, without impacting the endogenous expression of the Trhr gene.
The "P2A-Flpo" cassette was inserted upstream of TAA stop codon. Flpo recombinase is expressed under the regulatory control of Trhr gene elements, without impacting the endogenous expression of the Trhr gene.
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