Cd68-loxP-Stop-loxP-DTR
Product ID:
C001750
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Monocytes, neutrophils, Kupffer cells, microglia, macrophages, and Cd68-positive cells
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Strain Description
The loxP-3*SV40 pA-loxP-IRES-DTR-rBG pA cassette was inserted ~30 bp downstream of the TGA stop codon. Upstream of the DTR (diphtheria toxin receptor) gene lies a loxP-Stop-loxP cassette that blocks DTR transcription and expression. Upon Cre recombination, Cre-mediated deletion of the loxP-flanked stop (LSL) element enables DTR expression in Cre-positive cells. Intravenous administration of diphtheria toxin (DT) then selectively ablates these cells.
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