NKG-H2-Ab1 KO
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Basic Information
Model Name
NKG-H2-Ab1 KO
Product ID
C001498
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta
Classification
Immunodeficient Mouse Models
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “NKG-H2-Ab1 KO mice (Catalog C001498) were purchased from Cyagen.”
Strain Description
NKG-H2-Ab1 KO mice are generated by knocking out the H2-Ab1 gene on the background of NKG mice. Compared to NKG mice, NKG-H2-Ab1 KO mice can effectively reconstitute CD8+ T cells and exhibit improved survival after PBMC transplantation. They can be used for long-term studies on PBMC immune system reconstitution.
Application Area
Establishment of humanized immune system mouse model
Research on graft-versus-host disease (GvHD)
Research on the immune system, hematopoietic system, and blood disease
Cell line-derived xenograft (CDX) and drug screening and efficacy evaluation
Patient-derived xenograft (PDX) and drug screening and efficacy evaluation
Validation Data