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- ● Diet-Induced Obesity (DIO) Mouse Model
- ● Type 1 Diabetes Mellitus (T1DM) Mouse Model
- ● Type 2 Diabetes Mellitus (T2DM) Mouse Model
- ● Diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Chemically Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)
- ● Composite (Combined) Model - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Model
- ● Composite Model - Atherosclerosis Mouse Model
- ● Atherosclerosis Mouse Model (Gene-editing)
- ● Acute Pancreatitis Mouse Model
- ● Chronic Pancreatitis Mouse Model
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Tlx1-CreERT2-Venus Mice
Catalog Number: C001676
Strain Name: C57BL/6JCya-Tlx1em1(CreERT2-Venus)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: Developing spleen, kidneys, nervous system, mesenchymal tissues, and Tlx1-positive cells
Strain Description
The ATG start codon and the partial coding sequence of exon 1 were replaced with the Kozak-CreERT2-IRES-Venus-WPRE-BGH pA cassette. CreERT2 recombinase and Venus fluorescent protein are expressed under the regulatory control of Tlx1 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in Tlx1-positive cells following Tamoxifen induction.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome 19. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.
