B6-hCTLA4
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCTLA4
Product ID
C001413
Gene Name
Background
C57BL/6NCya
Gene Alias
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Neurological Disease Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
2
Document
Note: When using this mouse strain in a publication, please cite “B6-hCTLA4 mice (Catalog C001413) were purchased from Cyagen.”
Strain Description
This strain was generated by gene editing to replace the extracellular domain of Ctla4 in mice with the humanized version, resulting in a model that expresses the extracellular domain of human CTLA4 and the intracellular domain of mouse CTLA4. This model can be used for the research of the development and screening of CTLA4-related inhibitors or antibody drugs, the evaluation of pharmacodynamics and safety, the evaluation of tumor immunotherapy, and the mechanisms of the immune system.
Application Area
Development and screening of CTLA4-targeted inhibitors/antibody drugs
Evaluation of the efficacy and safety of CTLA4-targeted inhibitors/antibody drugs
Evaluation of tumor immunotherapy and research on the mechanisms of the immune system
Research on autoimmune diseases
Validation Data