NKG-SGM3/hIL6/Kit*V831M
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
NKG-SGM3/hIL6/Kit*V831M
Product ID
C001695
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); IL-3; MCGF; MULTI-CSF; CSF; GMCSF; SF; MGF; SCF; SLF; DCUA; FPH2; FPHH; KL-1; Kitl; WS2F; SHEP7; DFNA69; CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2; W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3
Classification
Immunodeficient Mouse Models
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “NKG-SGM3/hIL6/Kit*V831M mice (Catalog C001695) were purchased from Cyagen.”
Strain Description
NKG-SGM3/hIL6/Kit*V831M mice are mouse models obtained by mating KIT W41 mutation (V831M) mouse models (Catalog Number: I001175) with IL6 humanized mouse models (Catalog Number: I001176) and IL3, KITLG and CSF2 triple humanized mouse models (Catalog Number: I001177). These mice express human IL6, IL3, KITLG, and CSF2 genomic sequences, as well as mouse KIT genomic sequences carrying the W41 mutation (V831M). This model is a valuable tool for immuno-oncology, immunology, and infectious disease research.
Application Area
Construction of humanized mouse models for the immune system
Studies on the human immune and hematopoietic systems
Xenotransplantation of human cell lines (CDX) for drug screening and efficacy evaluation
Xenotransplantation of patient-derived tumor tissues (PDX) for drug screening and efficacy evaluation
Validation Data