Serpina1 (a-e) KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Serpina1 (a-e) KO
Product ID
I001121
Gene Name
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Background
C57BL/6JCya
Gene Alias
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Classification
Rare Disease Models,Other Disease Models
NCBI ID
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Phenotype
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Chromosome
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Note: When using this mouse strain in a publication, please cite “Serpina1 (a-e) KO mice (Catalog I001121) were purchased from Cyagen.”
Strain Description
Serpina1 (a-e) KO mice are gene knockout (KO) models created by gene editing technology to knock out the protein-coding sequences of the Serpina1 (a-e) genes (homologous to the human SERPINA1 gene) in mice. Preliminary data indicate almost no expression of the Serpina1 gene in the liver of these mice, with no significant pulmonary abnormalities observed at 8 weeks of age. Serpina1 (a-e) KO mice can be used to study the pathogenic mechanisms of emphysema and chronic obstructive pulmonary disease (COPD), cirrhosis, and hepatocellular carcinoma, as well as to develop related therapeutic approaches.
Application Area
Pathogenesis research and therapeutic drug evaluation for emphysema and chronic obstructive pulmonary disease (COPD)
Pathogenesis research and therapeutic drug evaluation for liver cirrhosis or hepatocellular carcinoma
Validation Data