B6-hFUS
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hFUS
Product ID
I001191
Gene Name
Background
C57BL/6JCya
Gene Alias
TLS; ALS6; ETM4; FUS1; POMP75; altFUS; HNRNPP2
Classification
Full-Gene Humanized Models,Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
16
Document
Note: When using this mouse strain in a publication, please cite “B6-hFUS mice (Catalog I001191) were purchased from Cyagen.”
Strain Description
This strain is a mouse Fus gene humanized model and can be used for research on ALS. The homozygous B6-hFUS mice are viable and fertile. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate hot mutation models based on this strain (e.g. FUS (p.R521C)) and provide customized services for specific mutations to meet the experimental needs in pharmacology and other fields related to ALS.
Application Area
Research on amyotrophic lateral sclerosis (ALS)
Research on frontotemporal lobar degeneration/dementia (FTLD-FUS)
Validation Data