B6-hGPR75 (1)
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hGPR75 (1)
Product ID
C001613
Gene Name
Background
C57BL/6JCya
Gene Alias
GPRchr2; WI31133
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hGPR75 (1) mice (Catalog C001613) were purchased from Cyagen.”
Strain Description
The B6-hGPR75 (1) mouse is a humanized model generated through gene editing technology, in which part of the mouse Gpr75 gene sequence is replaced in situ with the human GPR75 gene sequence. Homozygous B6-hGPR75 (1) mice are viable and fertile. This model can be used to study the pathological mechanisms and therapeutic interventions for obesity, metabolic diseases, and cardiovascular diseases, as well as for screening, developing, and evaluating the safety of GPR75-targeted drugs.
Application Area
GPR75-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of obesity, metabolic syndrome, cardiovascular disease, and cancer
Validation Data