B6-hNLRP3
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Genotype
Sex
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Basic Information
Model Name
B6-hNLRP3
Product ID
C001616
Gene Name
Background
C57BL/6NCya
Gene Alias
AII; AVP; FCU; MWS; FCAS; KEFH; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; DFNA34; PYPAF1; AGTAVPRL
Classification
Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-hNLRP3 mice (Catalog C001616) were purchased from Cyagen.”
Strain Description
B6-hNLRP3 mouse model was generated by replacing the mouse Nlrp3 genomic region (from the ATG start codon to ~500 bp downstream of the 3'UTR) with the human NLRP3 sequence (from 6 bp upstream of the ATG start codon to ~800 bp downstream of the 3'UTR), enabling stable expression of human NLRP3 protein. The B6-hNLRP3 mouse is suitable for studying inflammatory mechanisms, autoimmune diseases, neurodegenerative diseases, and metabolic diseases. It also serves as an ideal tool for human NLRP3-targeted drug development and preclinical efficacy evaluation.
Application Area
Studies of the immune system and inflammasome activation mechanisms
Pathological mechanism analysis of cryopyrin-associated periodic syndromes (CAPS)
Development, screening, and preclinical pharmacodynamic evaluation of NLRP3-targeted drugs
Neuroinflammation modulation research in neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease)
Exploration of mechanisms in metabolic diseases and autoimmune diseases
Validation Data