Rpe65 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Rpe65 KO
Product ID
C001387
Gene Name
Background
C57BL/6JCya
Gene Alias
LCA2; RP20; rd12; 65kDa; Mord1; A930029L06Rik
Classification
Ophthalmic Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “Rpe65 KO mice (Catalog C001387) were purchased from Cyagen.”
Strain Description
This product is a mouse Rpe65 knockout model that uses gene editing technology to knock out the homolog of the human RPE65 gene in mice. The deletion of Rpe65 gene expression in mice resulted in disruption of RPE cell function, apoptosis of photoreceptor cells, disorganization of the outer segmental discs of optic rods, and quenching of optic rod waveforms, causing severe retinal degeneration.
Application Area
Retinal Degeneration (RD) Research
Leber Congenital Amaurosis 2 (LCA2) Research
Other Retinal Disease Research
Validation Data