huHSC-NKG-ProF
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
huHSC-NKG-ProF
Product ID
C001543
Gene Name
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c)
Classification
Immunodeficient Mouse Models,Humanized Immune System Models,Autoimmune Disease Models
NCBI ID
Phenotype
--
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “huHSC-NKG-ProF mice (Catalog C001543) were purchased from Cyagen.”
Strain Description
The huHSC-NKG-ProF mouse is the latest enhanced version of the huHSC-NKG series, where "Pro" indicates the enhanced series and "F" indicates full immune reconstitution. This mouse model uses advanced neonatal techniques optimised to develop a variety of human immune cells, including lymphoid T cells, B cells and NK cells, as well as myeloid dendritic cells (DCs), monocytes, macrophages and granulocytes. Due to its ability to reconstitute multiple types of human-derived immune cells, the huHSC-NKG-ProF mouse is also referred to as a fully humanised immune system mouse. It is an ideal model for immunological research, antibody-dependent cellular cytotoxicity (ADCC) studies and the development of tumor vaccines, cellular therapies and other biopharmaceuticals.
Application Area
Tumor Immunology Research: Development of drugs such as immune checkpoint inhibitors, tumor vaccines, allogeneic cell therapies, and oncolytic viruses, as well as investigations into mechanisms that reverse T cell exhaustion, antibody-dependent cellular cytotoxicity (ADCC), and tumor-specific immunity
Autoimmune Disease Research: Evaluation of the mechanisms underlying the onset of autoimmune diseases and the exploration of therapeutic strategies
Drug Metabolism and Toxicity Research: Assessment of candidate compounds' pharmacokinetic properties and toxic effects in vivo
Validation Data
References