Tumor models, which involve the transplantation of human-derived tumor cells (or tissues) into mice, are used as a research model to study the mechanisms of disease and drug screening. Mouse tumor models are an indispensable tool to study the developmental pathology of tumors, and related drug screening and efficacy evaluations.
Cyagen’s animal model platform for drug research and development can provide various custom tumor models, tumor cell line transplantation models, and human tumor xenotransplantation models (CDX) according to your research needs. We can develop all kinds of tumor models – including subcutaneous, in situ or metastatic – and provide highly customized pharmacodynamic services for the corresponding models to meet your research needs.
|Homologous tumor transplantation model (Syngeneic)||
The syngeneic model (also known as allograft mouse tumor systems) involves inoculation of tumor cell lines (derived from the same genetic background strain) which are implanted into the inbred immunocompetent mouse strain. The recipient mouse has an intact native immune system and normal immune response, and its immune system is compatible with the transplanted tumor tissue - which together maximize the simulation of the real-life tumor microenvironment. However, the transplanted mouse tissue may not fully represent the complexity of human tumors in clinical cases.
|Human cell line-derived tumor xenograft (CDX) model||
The human cell line-derived tumor xenograft (CDX) model, one of the commonly used models for studying tumor cell proliferation and in vivo drug screening, involves inoculation of tumor cells (subcultured in vitro) into immunodeficient mice. Due to the long-term cell passage in vitro, they have the characteristics of high homology, easy construction, and reproducibility. However, in the process of continuous culture and passaging, tumor heterogeneity is quite different from the original tumor tissue.