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Abca4 KO
Product ID:
I001134
Strain:
C57BL/6JCya
Status:
Description:
This strain is an Abca4 gene knockout (KO) mouse model. Gene-editing technology was used to delete the protein-coding sequence of the Abca4 gene (the homolog of the human ABCA4 gene) in mice. Previous studies have demonstrated that Abca4 KO mice exhibit delayed dark adaptation following photobleaching and a slow progression of photoreceptor degeneration. Homozygous Abca4 KO mice are viable and fertile.
This strain is an Abca4 gene knockout (KO) mouse model. Gene-editing technology was used to delete the protein-coding sequence of the Abca4 gene (the homolog of the human ABCA4 gene) in mice. Previous studies have demonstrated that Abca4 KO mice exhibit delayed dark adaptation following photobleaching and a slow progression of photoreceptor degeneration. Homozygous Abca4 KO mice are viable and fertile.
B6-Rpe65 R44X
Product ID:
C001360
Strain:
C57BL/6JCya
Status:
Description:
This model was constructed by introducing the Rpe65 R44X point mutation into the mouse gene by gene editing techniques, resulting in a C to T base substitution at nucleotide 130 of the gene encoding the Rpe65 protein, leading to a stop codon at amino acid position 44 instead of arginine (p.R44*). It has been reported that the eyes of homozygous mice carrying this mutation will not express the RPE65 protein 3. This model can be used in studies of retinitis pigmentosa 20 (RP20), Leber's congenital amaurosis type 2 (LCA 2), and the visual cycle.
This model was constructed by introducing the Rpe65 R44X point mutation into the mouse gene by gene editing techniques, resulting in a C to T base substitution at nucleotide 130 of the gene encoding the Rpe65 protein, leading to a stop codon at amino acid position 44 instead of arginine (p.R44*). It has been reported that the eyes of homozygous mice carrying this mutation will not express the RPE65 protein 3. This model can be used in studies of retinitis pigmentosa 20 (RP20), Leber's congenital amaurosis type 2 (LCA 2), and the visual cycle.
B6-hABCA4
Product ID:
C001551
Strain:
C57BL/6JCya
Status:
Description:
This strain is a mouse Abca4 gene humanized model and can be used to research STGD, CRD, and RP. The homozygous B6-hABCA4 mice are viable and fertile. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate hot mutation (ABCA4 c.5461-10 T to C) models based on this strain and provide customized services for specific mutations to meet the experimental needs in pharmacology and other fields.
This strain is a mouse Abca4 gene humanized model and can be used to research STGD, CRD, and RP. The homozygous B6-hABCA4 mice are viable and fertile. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate hot mutation (ABCA4 c.5461-10 T to C) models based on this strain and provide customized services for specific mutations to meet the experimental needs in pharmacology and other fields.
B6-hABCA4*c.5461-10T>C
Product ID:
I001210
Strain:
C57BL/6JCya
Status:
Description:
The B6-hABCA4*c.5461-10T>C mouse is a humanized model of the Abca4 gene, where the mouse Abca4 gene has been replaced with the human ABCA4 gene carrying the c.5461-10T>C mutation using gene editing technology. This model can be used for research on various retinal degeneration diseases such as Stargardt disease (STGD), cone-rod dystrophy (CRD), and retinitis pigmentosa (RP).
The B6-hABCA4*c.5461-10T>C mouse is a humanized model of the Abca4 gene, where the mouse Abca4 gene has been replaced with the human ABCA4 gene carrying the c.5461-10T>C mutation using gene editing technology. This model can be used for research on various retinal degeneration diseases such as Stargardt disease (STGD), cone-rod dystrophy (CRD), and retinitis pigmentosa (RP).
B6-hANG2 (ANGPT2)
Product ID:
C001615
Strain:
C57BL/6JCya
Status:
Description:
B6-hANG2 (ANGPT2) mouse model was generated using gene editing technology to replace the entire sequence of the mouse Angpt2 gene with the human ANGPT2 gene sequence, achieving stable expression of human ANGPT2 protein. This model is suitable for studying tumorigenesis, vascular hyperproliferative diseases (e.g., diabetic retinopathy, age-related macular degeneration), autoimmune disorders, and preclinical evaluation of human ANGPT2-targeted therapeutics.
B6-hANG2 (ANGPT2) mouse model was generated using gene editing technology to replace the entire sequence of the mouse Angpt2 gene with the human ANGPT2 gene sequence, achieving stable expression of human ANGPT2 protein. This model is suitable for studying tumorigenesis, vascular hyperproliferative diseases (e.g., diabetic retinopathy, age-related macular degeneration), autoimmune disorders, and preclinical evaluation of human ANGPT2-targeted therapeutics.
B6-hANGPTL7
Product ID:
C001789
Strain:
C57BL/6JCya
Status:
Description:
The B6-hANGPTL7 mouse is a humanized model, constructed by replacing the sequences from 5'UTR to 3'UTR of the endogenous mouse Angptl7 gene with the corresponding human ANGPTL7 gene sequence. B6-hANGPTL7 mice can be used for research into the pathogenesis of glaucoma, type 2 diabetes mellitus (T2DM), and obstructive sleep apnea (OSA). They are also useful for the screening, development, and safety evaluation of ANGPTL7-targeted drugs.
The B6-hANGPTL7 mouse is a humanized model, constructed by replacing the sequences from 5'UTR to 3'UTR of the endogenous mouse Angptl7 gene with the corresponding human ANGPTL7 gene sequence. B6-hANGPTL7 mice can be used for research into the pathogenesis of glaucoma, type 2 diabetes mellitus (T2DM), and obstructive sleep apnea (OSA). They are also useful for the screening, development, and safety evaluation of ANGPTL7-targeted drugs.
B6-hC3
Product ID:
I001135
Strain:
C57BL/6JCya
Status:
Description:
The B6-hC3 mouse is a mouse C3 humanized model created by replacing the mouse C3 gene with the human C3 gene using gene-editing technology. The humanized regions include the 5’UTR and 3’UTR. Under natural breeding conditions, homozygous B6-hC3 mice exhibit mortality around 10 weeks of age, and it has been observed that heterozygous mice also experience mortality.
The B6-hC3 mouse is a mouse C3 humanized model created by replacing the mouse C3 gene with the human C3 gene using gene-editing technology. The humanized regions include the 5’UTR and 3’UTR. Under natural breeding conditions, homozygous B6-hC3 mice exhibit mortality around 10 weeks of age, and it has been observed that heterozygous mice also experience mortality.
B6-hC3/hTFRC (CDS)
Product ID:
C001608
Strain:
C57BL/6JCya;C57BL/6NCya
Status:
Description:
The B6-hC3/hTFRC (CDS) mouse model is a humanized model obtained by breeding B6-hC3 mice (Catalog No.: I001135) with B6-hTFRC (CDS) mice (Catalog No.: C001584). This model can be used for research on complement-mediated diseases, iron metabolism disorders, neurodegenerative diseases, and tumor development, aiding in studying C3/TFRC-targeted drugs.
The B6-hC3/hTFRC (CDS) mouse model is a humanized model obtained by breeding B6-hC3 mice (Catalog No.: I001135) with B6-hTFRC (CDS) mice (Catalog No.: C001584). This model can be used for research on complement-mediated diseases, iron metabolism disorders, neurodegenerative diseases, and tumor development, aiding in studying C3/TFRC-targeted drugs.
B6-hC5
Product ID:
C001824
Strain:
C57BL/6JCya
Status:
Description:
The B6-hC5 mouse model is a humanized model of the Hc gene, with the mouse Hc gene homologous to the human C5 gene. Using gene-editing technology, the mouse Hc gene was replaced with the human C5 gene while retaining the mouse signal peptide; the humanized region also includes the 3’ UTR. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate mutation models based on this strain and provide customized services.
The B6-hC5 mouse model is a humanized model of the Hc gene, with the mouse Hc gene homologous to the human C5 gene. Using gene-editing technology, the mouse Hc gene was replaced with the human C5 gene while retaining the mouse signal peptide; the humanized region also includes the 3’ UTR. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate mutation models based on this strain and provide customized services.
B6-hCEP290
Product ID:
I001217
Strain:
C57BL/6JCya
Status:
Description:
This strain is a humanized mouse model of Cep290, in which the endogenous mouse Cep290 gene is replaced by the human CEP290 gene using gene-editing technology. It can be used to study Leber Congenital Amaurosis type 10 (LCA10).
This strain is a humanized mouse model of Cep290, in which the endogenous mouse Cep290 gene is replaced by the human CEP290 gene using gene-editing technology. It can be used to study Leber Congenital Amaurosis type 10 (LCA10).
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