Name: huHSC-NKG-ProF Mouse
Brand: Cyagen
SKU: C001543
Availability: InStock

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huHSC-NKG-ProF Mouse

Product Name

huHSC-NKG-ProF Mouse

Product ID

C001543

Strain Name

huHSC-ProF-NOD.Cg-Prkdc^scidIl2rg^em1cya/Cya

Backgroud

NKG

Status

When using this mouse strain in a publication, please cite “huHSC-NKG-ProF Mouse (Catalog C001543) were purchased from Cyagen.”

Immunodeficient Mice Humanized Immune System Models

Product Type

Age

Genotype

Sex

Quantity

Immunodeficient Mice Humanized Immune System Models

Basic Information

Validation Data

Related Resource

Basic Information

Gene Name

Il2rg

Gene Alias

NCBI ID

16186 (Mouse)

Chromosome

Chr X (Mouse)

MGI ID

Datasheet

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Strain Description

NKG mice (Catalog number: C001316) are a kind of severe immunodeficient mice generated by Cyagen through deleting the Il2rg gene from NOD-Scid mice. NKG mice exhibit deficiency of mature T cells, B cells, and functional NK cells, reduced complement activity, and weak phagocytosis of human-derived cells by macrophages, which are well suited for the transplantation of human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), adult stem cells and tissues, and patient-derived xenograft (PDX).

huHSC-NKG mice are immune system humanized mouse models constructed by transplanting human hematopoietic stem cells (HSC) into NKG mice after sub-lethal dose irradiation. This model has a long lifespan and can successfully reconstitute various immune cells. In addition, huHSC-NKG mice typically do not develop graft-versus-host disease (GvHD) and the reconstitution period can be long.

The huHSC-NKG-ProF mouse is the latest enhanced version of the huHSC-NKG series, where "Pro" indicates the enhanced series and "F" indicates full immune reconstitution. This mouse model uses advanced neonatal techniques optimised to develop a variety of human immune cells, including lymphoid T cells, B cells and NK cells, as well as myeloid dendritic cells (DCs), monocytes, macrophages and granulocytes. Due to its ability to reconstitute multiple types of human-derived immune cells, the huHSC-NKG-ProF mouse is also referred to as a fully humanised immune system mouse. It is an ideal model for immunological research, antibody-dependent cellular cytotoxicity (ADCC) studies and the development of tumor vaccines, cellular therapies and other biopharmaceuticals.

Application Area

Tumor Immunology Research: Development of drugs such as immune checkpoint inhibitors, tumor vaccines, allogeneic cell therapies, and oncolytic viruses, as well as investigations into mechanisms that reverse T cell exhaustion, antibody-dependent cellular cytotoxicity (ADCC), and tumor-specific immunity；

Autoimmune Disease Research: Evaluation of the mechanisms underlying the onset of autoimmune diseases and the exploration of therapeutic strategies；

Drug Metabolism and Toxicity Research: Assessment of candidate compounds' pharmacokinetic properties and toxic effects in vivo.

Validation Data

Related Resource

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