This strain is a mouse Tub knockout model that uses gene editing technology to knock out the homolog of the human TUB gene in mice. The Tub knockout mouse model has been reported to have the same phenotype as Tubby mice carrying spontaneous mutations in the Tub gene, and the deletion of Tub gene expression in mice leads to abnormalities of photoreceptors in the retina through apoptosis, which subsequently causes defects in the retina, and this model can be used for the study of retinal degeneration and related diseases. The homozygous Tub-KO mice are viable and fertile, but the phenomenon of filial cannibalism is more pronounced in homozygotes.