B6-hBAFFR (hTNFRSF13C)
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Strain Description
The B6-hBAFFR (hTNFRSF13C) mouse is a humanized model constructed by replacing the sequence of the mouse Tnfrsf13c endogenous extracellular domain (aa.1~71) in situ with the corresponding extracellular domain (aa.1~78) from the human TNFRSF13C. The B6-hBAFFR (hTNFRSF13C) mice can be used for the study of the pathogenesis of immune-mediated disorders such as common variable immunodeficiency (CVID), systemic lupus erythematosus (SLE), and Sjögren's syndrome, and certain B cell malignancies, as well as for TNFRSF13C-targeted drug development.
Application Area
TNFRSF13C-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of immune-mediated disorders such as common variable immunodeficiency (CVID), systemic lupus erythematosus (SLE), and Sjögren's syndrome
Research on the pathological mechanisms and therapeutic approaches of certain B cell malignancies
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