AG129
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
AG129
Product ID
C001893
Background
129S2/SvPasCya
Gene Alias
Ifar; Ifrc; Ifnar; Infar; Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
Classification
Immunodeficient Mouse Models,Infectious Disease Models
Phenotype
Chromosome
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Datasheet
Note: When using this mouse strain in a publication, please cite “AG129 mice (Catalog C001893) were purchased from Cyagen.”
Strain Description
AG129 mice, which are knockout models for both the type I (α/β) IFN receptor (Ifnar1) and the type II (γ) IFN receptor (Ifngr1), lack functional IFNAR1 and IFNGR1 proteins, resulting in deficiencies in α/β/γ interferon receptor signaling and heightened susceptibility to viral infections. Homozygous AG129 mice are viable and fertile, and exhibit increased sensitivity to arboviral infections, generating viremia similar to that seen in humans. Compared to IFNα/β/γR KO mice on the C57BL/6 background, the 129-background AG129 mice exhibit more pronounced neurological symptoms after infection.
Application Area
Investigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV
Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
Validation Data