TG-hSERPINA1*E366K
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
TG-hSERPINA1*E366K
Product ID
I001123
Gene Name
Background
C57BL/6JCya
Gene Alias
PI; A1A; AAT; PI1; A1AT; nNIF; PRO2275; alpha1AT
Classification
Other Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “TG-hSERPINA1*E366K mice (Catalog I001123) were purchased from Cyagen.”
Strain Description
The TG-hSERPINA1*E366K mouse is generated by integrating the Human SERPINA1 Genomic DNA (the region from ~5kb upstream of exon 1 to ~3kb downstream of exon 5) into the mouse genome via transgenesis (TG) technology. A p.E366K (GAG to AAG) point mutation is introduced into exon 5 of this integrated human SERPINA1 sequence. This model can be used to study diseases such as alpha-1 antitrypsin deficiency (AATD), emphysema, chronic obstructive pulmonary disease (COPD), cirrhosis, and hepatocellular carcinoma, as well as to develop relevant therapeutic strategies.
Application Area
Research on alpha-1 antitrypsin deficiency (AATD)
Research on emphysema and chronic obstructive pulmonary disease (COPD)
Research on cirrhosis or hepatocellular carcinoma
Validation Data