C57BL/6JCya-Skiem1flox/Cya
Common Name
Ski-flox
Product ID
S-CKO-05072
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20481-Ski-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ski-flox Mouse (Catalog S-CKO-05072) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ski-flox
Strain ID
CKOCMP-20481-Ski-B6J-VA
Gene Name
Product ID
S-CKO-05072
Gene Alias
2310012I02Rik, 2610001A11Rik
Background
C57BL/6JCya
Gene Full Name
ski sarcoma viral oncogene homolog (avian)
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 4 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000030917
NCBI Transcript ID
NM_011385
Target Region
Exon 2~3
Size of Effective Region
~1.1 kb
Overview of Gene Research
Ski, also known as Sloan-Kettering Institute protein, is an evolutionarily conserved protein involved in diverse cellular processes. It acts as both an oncoprotein and tumor suppressor gene, mediating cell proliferation, differentiation, metastasis, and invasion in various cancers [1]. Ski is also implicated in regulating key signaling pathways such as the TGFβ pathway [2].
Loss-of-function studies have provided insights into Ski's role. Loss of one copy of mouse ski increases susceptibility to tumorigenesis in mice, while its overexpression is associated with cancer progression in human melanoma, esophageal, breast, and colon cancers [3]. In Th17-related diseases, SKI expression suppresses pathogenic Th17 cell response. Ectopic SKI expression in T cells prevented experimental autoimmune encephalomyelitis, an animal model of human multiple sclerosis [4].
In conclusion, Ski plays dual roles in cancer development, and its dysregulation is associated with tumorigenesis and cancer progression. In addition, Ski is crucial in regulating pathogenic Th17 cell-related autoimmune diseases. The use of mouse models in these studies has significantly enhanced our understanding of Ski's functions in disease, providing potential targets for therapeutic intervention.
References：
1. Liao, Hai-Yang, Da, Chao-Ming, Wu, Zuo-Long, Zhang, Hai-Hong. 2020. Ski: Double roles in cancers. In Clinical biochemistry, 87, 1-12. doi:10.1016/j.clinbiochem.2020.10.015. https://pubmed.ncbi.nlm.nih.gov/33188772/
2. Bonnon, Carine, Atanasoski, Suzana. 2011. c-Ski in health and disease. In Cell and tissue research, 347, 51-64. doi:10.1007/s00441-011-1180-z. https://pubmed.ncbi.nlm.nih.gov/21647564/
3. Reed, Jon A, Lin, Qiushi, Chen, Dahu, Mian, I Saira, Medrano, Estela E. . SKI pathways inducing progression of human melanoma. In Cancer metastasis reviews, 24, 265-72. doi:. https://pubmed.ncbi.nlm.nih.gov/15986136/
4. Li, Ping, Guo, Zengli, Wan, Yisong Y. 2021. SKI Expression Suppresses Pathogenic Th17 Cell Response and Mitigates Experimental Autoimmune Encephalomyelitis. In Frontiers in immunology, 12, 707899. doi:10.3389/fimmu.2021.707899. https://pubmed.ncbi.nlm.nih.gov/34335622/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
