C57BL/6JCya-Tmed1em1/Cya
Common Name:
Tmed1-KO
Product ID:
S-KO-20408
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Tmed1-KO
Strain ID
KOCMP-17083-Tmed1-B6J-VC
Gene Name
Product ID
S-KO-20408
Gene Alias
Il1rl1l; Ly84l; St2l
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tmed1em1/Cya mice (Catalog S-KO-20408) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034698
NCBI RefSeq
NM_010744
Target Region
Exon 2~4
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
TMED1, also known as p24γ1, is a member of the transmembrane emp24 domain-containing (TMED) protein family. These proteins are crucial for intracellular protein transport, especially in the bidirectional transport between the endoplasmic reticulum (ER) and the Golgi apparatus, which is essential for normal embryonic development and various cellular functions [1,3,4].
In colorectal cancer (CRC), integrative multi-omics analysis shows that highly expressed TMED1 is related to poor prognosis. Knocking down TMED1 reduces cell growth and increases apoptosis. Its expression is positively correlated with other TMED family members in CRC and is associated with immune cell infiltration and drug resistance [2]. In C. elegans, tmed-1 (homologous to human TMED1) can compensate for tmed-3 in some functions, and mutants of these genes show defects in embryonic viability, movement, and vulval morphology, suggesting a role in tissue reorganization during development [4].
In conclusion, TMED1 plays a significant role in protein vesicular trafficking and is involved in important biological processes such as development and disease-related events like in colorectal cancer. Studies in genetic models like C. elegans and through knockdown experiments in CRC cells have provided insights into its functions, highlighting its potential as a prognostic biomarker and therapeutic target in certain diseases.
References:
1. Mota, Danielly C A M, Cardoso, Iara A, Mori, Renan M, Costa-Filho, Antonio J, Mendes, Luis F S. 2021. Structural and thermodynamic analyses of human TMED1 (p24γ1) Golgi dynamics. In Biochimie, 192, 72-82. doi:10.1016/j.biochi.2021.10.002. https://pubmed.ncbi.nlm.nih.gov/34634369/
2. Guo, Xin, Zhou, Wei, Jin, Jinmei, Zhang, Lijun, Luan, Xin. 2024. Integrative Multi-Omics Analysis Identifies Transmembrane p24 Trafficking Protein 1 (TMED1) as a Potential Prognostic Marker in Colorectal Cancer. In Biology, 13, . doi:10.3390/biology13020083. https://pubmed.ncbi.nlm.nih.gov/38392302/
3. Zhou, Lv, Li, Huaixu, Yao, Hui, Gao, Peng, Cheng, Hongwei. 2023. TMED family genes and their roles in human diseases. In International journal of medical sciences, 20, 1732-1743. doi:10.7150/ijms.87272. https://pubmed.ncbi.nlm.nih.gov/37928880/
4. Navarro, Kristen G, Chamberlin, Helen M. 2023. Genetic characterization of C. elegans TMED genes. In Developmental dynamics : an official publication of the American Association of Anatomists, 252, 1149-1161. doi:10.1002/dvdy.601. https://pubmed.ncbi.nlm.nih.gov/37204056/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen