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Animal Models
C57BL/6JCya-Ocmem1/Cya
Ocm is located on chromosome 5 of mice. Nuclease Technology was used to design sgRNA; Ocm knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Ccm2em1/Cya
Ccm2 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Ccm2 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Icmtem1/Cya
Icmt is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Icmt knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Ocmem1flox/Cya
Ocm is located on chromosome 5 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Ocm conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6NCya-Cmahem1/Cya
Cmah is located on chromosome 13 of mice. Nuclease Technology was used to design sgRNA; Cmah knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6NCya-Cmahem1/Cya
Cmah is located on chromosome 13 of mice. Nuclease Technology was used to design sgRNA; Cmah knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Ecm1em1/Cya
Ecm1 is located on chromosome 3 of mice. Nuclease Technology was used to design sgRNA; Ecm1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Cmblem1/Cya
Cmbl is located on chromosome 15 of mice. Nuclease Technology was used to design sgRNA; Cmbl knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Gcm1em1/Cya
Gcm1 is located on chromosome 9 of mice. Nuclease Technology will be used to design sgRNA; Gcm1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Mcm6em1/Cya
Mcm6 is located on chromosome 1 of mice. Nuclease Technology will be used to design sgRNA; Mcm6 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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