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Animal Models
C57BL/6JCya-Wnk1em1/Cya
Wnk1 is located on chromosome 6 of mice. Nuclease Technology was used to design sgRNA; Wnk1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Twnkem1/Cya
Twnk is located on chromosome 19 of mice. Nuclease Technology will be used to design sgRNA; Twnk knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnk4em1/Cya
Wnk4 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Wnk4 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnt4em1/Cya
Wnt4 is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Wnt4 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnt3em1/Cya
Wnt3 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Wnt3 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnt2em1/Cya
Wnt2 is located on chromosome 6 of mice. Nuclease Technology will be used to design sgRNA; Wnt2 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnt1em1/Cya
Wnt1 is located on chromosome 15 of mice. Nuclease Technology will be used to design sgRNA; Wnt1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnt6em1/Cya
Wnt6 is located on chromosome 1 of mice. Nuclease Technology will be used to design sgRNA; Wnt6 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnk2em1/Cya
Wnk2 is located on chromosome 13 of mice. Nuclease Technology will be used to design sgRNA; Wnk2 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Wnk3em1/Cya
Wnk3 is located on chromosome X of mice. Nuclease Technology will be used to design sgRNA; Wnk3 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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