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Animal Models
C57BL/6NCya-Cfdem1/Cya
Cfd is located on chromosome 10 of mice. Nuclease Technology will be used to design sgRNA; Cfd knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Cfdem1/Cya
Cfd is located on chromosome 10 of mice. Nuclease Technology will be used to design sgRNA; Cfd knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Bzw1em1/Cya
Bzw1 is located on chromosome 1 of mice. Nuclease Technology was used to design sgRNA; Bzw1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Zw10em1/Cya
Zw10 is located on chromosome 9 of mice. Nuclease Technology will be used to design sgRNA; Zw10 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Bzw2em1/Cya
Bzw2 is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Bzw2 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Zwintem1/Cya
Zwint is located on chromosome 10 of mice. Nuclease Technology was used to design sgRNA; Zwint knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Cfdem1flox/Cya
Cfd is located on chromosome 10 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Cfd conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Scfd1em1/Cya
Scfd1 is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Scfd1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Mcfd2em1/Cya
Mcfd2 is located on chromosome 17 of mice. Nuclease Technology was used to design sgRNA; Mcfd2 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Cfdp1em1/Cya
Cfdp1 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Cfdp1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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