C57BL/6JCya-Ideem1/Cya
Common Name
Ide-KO
Product ID
S-KO-17912
Backgroud
C57BL/6JCya
Strain ID
KOCMP-15925-Ide-B6J-VB
Status
When using this mouse strain in a publication, please cite “Ide-KO Mouse (Catalog S-KO-17912) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ide-KO
Strain ID
KOCMP-15925-Ide-B6J-VB
Gene Name
Product ID
S-KO-17912
Gene Alias
1300012G03Rik, 4833415K22Rik
Background
C57BL/6JCya
Gene Full Name
insulin degrading enzyme
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 19 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000131070
NCBI Transcript ID
NM_031156
Target Region
Exon 3
Size of Effective Region
~0.2 kb
Overview of Gene Research
IDE, short for Insulin-degrading enzyme, is an evolutionarily conserved zinc-dependent metallopeptidase. It plays a crucial role in various biological processes. Besides degrading insulin, IDE can cleave many substrates in vitro, including amyloid beta peptides, suggesting its potential link in the pathophysiology between Alzheimer's disease (AD) and type 2 diabetes (T2D) [1].
In IDE knockout (IDE-KO) mice, a specific induction of microgliosis was found in the hippocampus, and the performance on hippocampal-dependent memory tests in 12-month-old mice was influenced by IDE gene dose [1]. Additionally, IDE absence in primary microglial cultures altered microglial responses to environmental signals, resulting in impaired modulation of phenotypic states [1]. In Klf9-/-mice, which exhibit impaired cognitive function, overexpression of IDE in hippocampal neurons ameliorated cognitive deficits and reduced the Aβ content, indicating that IDE-mediated Aβ degradation is important in AD-related cognitive function [2].
In conclusion, IDE is a significant enzyme involved in multiple biological functions, especially in relation to AD and T2D. The use of IDE-KO mouse models has revealed its role in microglial phenotypes, hippocampal-dependent memory, and Aβ degradation in the context of AD, providing valuable insights into the underlying disease mechanisms.
References：
1. Corraliza-Gomez, Miriam, Bermejo, Teresa, Lilue, Jingtao, Sanchez, Diego, Ganfornina, Maria Dolores. 2023. Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging. In Journal of neuroinflammation, 20, 233. doi:10.1186/s12974-023-02914-7. https://pubmed.ncbi.nlm.nih.gov/37817156/
2. Feng, Yue-Yao, Hao, Jing-Ran, Zhang, Yu-Jie, Pan, Zhe, Chang, Yong-Sheng. 2025. Krüppel-like factor 9 alleviates Alzheimer's disease via IDE-mediated Aβ degradation. In Acta pharmacologica Sinica, , . doi:10.1038/s41401-025-01491-0. https://pubmed.ncbi.nlm.nih.gov/39962264/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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