Tlr3 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Tlr3 KO
Product ID
C001233
Gene Name
Background
C57BL/6NCya
Gene Alias
--
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
8
Document
Note: When using this mouse strain in a publication, please cite “Tlr3 KO mice (Catalog C001233) were purchased from Cyagen.”
Strain Description
This strain is a Tlr3 gene knockout (Tlr3 KO) mouse, which uses gene editing technology to knock out the Tlr3 gene in mice homologous to the human TLR3 gene. Homozygous Tlr3 KO mice are viable and fertile. Research shows that, unlike the macrophages of wild-type mice, the macrophages of Tlr3 KO mice cannot produce the inflammatory cytokines IFN-α or IFN-β when attacked by polyinosinic-polycytidylic acid. Primary splenocytes isolated from homozygous Tlr3 KO mice are unresponsive to viral dsRNA and have reduced IL-6 production.
Application Area
Studies related to the toll-like receptor pathway of the innate immune response, among others
Validation Data