Catalog Number: I001169
Strain Name: C57BL/6JCya-Adgre1em1(P2A-CreERT2)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: macrophages
Strain Description
The TAA stop codon was replaced with the "P2A-CreERT2" cassette. CreERT2 recombinase is expressed under the regulatory control of Adgre1 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in macrophages following Tamoxifen induction.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome 17. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.