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Catalog Number: I001170
Strain Name: C57BL/6JCya-Cd2em1(P2A-CreERT2)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: T cells and B cells
Strain Description
The TAA stop codon was replaced with the "P2A-CreERT2-WPRE-BGH pA" cassette. CreERT2 recombinase is expressed under the regulatory control of Cd2 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in T cells and B cells following Tamoxifen induction.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome 3. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.