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Catalog Number: I001151
Strain Name: C57BL/6JCya-Ins1em2(CreERT2)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: pancreatic β cells
Strain Description
The partial coding region of exon 2 of the mouse Ins1 gene was replaced with the "Kozak- CreERT2-WPRE-BGH pA" cassette. CreERT2 recombinase is expressed under the regulatory control of Ins1 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in the pancreas following Tamoxifen induction.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome 19. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.